Results 51 to 60 of about 598,469 (307)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Analysis of flow field characteristics in upper open area of luxury cruise ship
Zhongguo Jianchuan YanjiuObjectiveThe open area of the superstructure of a luxury cruise ship has a complex spatial layout and appearance modeling. In this study, the wind load and flow field characteristics in this area are accurately simulated to guide cruise ship design ...
Liujun ZHANG +3 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2019 A traditional hydrocyclone can only generate two products with different size fractions after one classification, which does not meet the fine classification requirements for narrow size fractions.
Yuekan Zhang +4 more
core +1 more source
Analysis of Mechanical Properties of SLCD-I Composite Cutter Milling Shoe
Shiyou jixie, 2020 SLCD-I composite cutter milling shoe is a kind of high-efficiency milling shoes popularized and applied in Shengli Oilfield. To improve the cutting efficiency and effectiveness of this type of milling shoe for fish in well, ANSYS Workbench engineering ...
Zhao Bo +6 more
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 2021 In order to evaluate the flow field characteristics of a marine diesel engine cooling water jacket, and provide a theoretical basis for further optimizing the water jacket structure.
Shaobo Yang +5 more
core +1 more source
SPH Simulation of Interior and Exterior Flow Field Characteristics of Porous Media [PDF]
, 2020 At the present time, one of the most relevant challenges in marine and ocean engineering and practice is the development of a mathematical modeling that can accurately replicate the interaction of water waves with porous coastal structures. Over the last
Wu, Shijie +5 more
core +1 more source
Study on Aerodynamic Noise of Ahmed Body Mounted with Different Spoiler Configurations
Applied SciencesThis study employs computational fluid dynamics methods to investigate the aerodynamic noise of a 35° inclination Ahmed body mounted with six hollow spoilers of different opening areas. The study combines the steady k-ε model and the transient large eddy
Zhi-Ping Wang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source