Results 71 to 80 of about 2,522,757 (310)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Turbulence and pressure loss characteristics of the inlet vanes for the 80- by 120-ft wind tunnel [PDF]

A series of wind tunnel investigations were conducted to determine the flow characteristics downstream of a set of wind tunnel inlet flow conditioning vanes.
Dudley, Michael R.
core   +1 more source

Flux Flow Effects in Annular Josephson Tunnel Junctions [PDF]

, 2019
We investigate Josephson flux-flow in annular Josephson tunnel junctions (AJTJs) under the application of magnetic fields generating finite-voltage steps in their current-voltage characteristics.
Koshelets, Valery P., Monaco, Roberto, Mygind, Jesper   +2 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Effect of Sand Content in Produced Liquid on Separation Performance of Axis-in Inverted Cone Hydrocyclone

Shiyou jixie, 2020
To study the application of downhole hydrocyclones in sand conditions and obtain the best separation effect, based on the computational fluid dynamics method, the Reynolds stress model is adopted, and the axis-in inverted cone hydrocyclone is taken as ...
Zhang Yong, Yin Cunxiao, Zhang Yan, Jiang Minghu, Xing Lei   +4 more
doaj  

Effects of geometric and flow-field variables on inverted-velocity-profile coaxial jet noise [PDF]

Relationships between the noise generation characteristics and the flow field characteristics for inverted-velocity-profile coaxial jets are discussed. Noise measurements were made at four different sideline distances in order to determine the apparent ...
Stone, J. R.
core   +1 more source

On the multispacecraft determination of periodic surface wave phase speeds and wavelengths [PDF]

, 2010
Observations of surface waves on the magnetopause indicate a wide range of phase velocities and wavelengths. Their multispacecraft analysis allows a more precise determination of wave characteristics than ever before and reveal shortcomings of ...
A. N. Fazakerley, Bai, Balogh, Belmont, C. Foullon, C. J. Farrugia, C. J. Owen, Chandrasekhar, Chen, Chen, De Keyser, De Keyser, De Keyser, Elphic, F. T. Gratton, Fairfield, Fairfield, Farrugia, Farrugia, Foullon, Foullon, Foullon, Foullon, Fujimoto, Hasegawa, Hasegawa, Hasegawa, Hasegawa, Hones, Kokubun, Lavraud, Manuel, Mills, Miura, Miura, Miura, Miura, Nykyri, Ogilvie, Otto, Owen, Phan, R. B. Torbert, Roelof, Russell, Saunders, Schwartz, Southwood, Thomas, Torrence, Walker, Wright, Wu   +52 more
core   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Adaptability Analysis of the LW350 Centrifuge Based on Fluid-Solid Coupling

Shiyou jixie, 2020
To study the flow field characteristics of the centrifuge and the mechanical characteristics of its key structures, taking the LW350 centrifuge for case study, a model of the centrifuge fluid domain and screw conveyor was established.
Liu Hongbin, Zhang Yihao, Liu Li, Huang Xiao, Zhu Tianji   +4 more
doaj  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source