Results 71 to 80 of about 598,469 (307)
Analysis of Strength and Flow Field Characteristics of CDD110B Rotary Milling Guide Shoe
Shiyou jixie, 2022 In order to improve the smoothness of side wall and the effectiveness of drifting operation,a new downhole spiral power dressing tool was designed.As the key part of the power dressing tool,the rotary milling guide shoe has the dual functions of sidewall
Hu Xinyu +6 more
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Study on Erosion Law of Large Diversion Surface Plunger Type Throttle Valve
Shiyou jixie, 2022 In order to explore the failure of the plunger type throttle valve due to high-speed particle impact and fluid erosion in the throttling process, taking the PCG, 2-9/16×15M throttle valve as the research object, the Euler-Lagrange method and ...
Feng Pengyun +4 more
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
, 2023 The produced water-containing polymer brings new challenges to oil-water separation in oilfield production, yet separators with coalescing plates to remove free water have been playing an active role.
Xiangdong Qi +7 more
core +2 more sources
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
, 1960 Force, moment, and flow field characteristics of two wing body nacelle combinations at Mach 2 and
Hill, W. A., Jr.
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
, 2021 Horizontal axis double-runner Francis turbines have great advantages in the development of small hydropower plants, but the arrangement of double runners aggravates the complexity of the water flow between runners, and the mutual influence of the two ...
Chunxia Yang +5 more
core +1 more source