Results 71 to 80 of about 3,838,736 (307)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

PatchBatch: A Batch Augmented Loss for Optical Flow [PDF]

2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR), 2016
We propose a new pipeline for optical flow computation, based on Deep Learning techniques. We suggest using a Siamese CNN to independently, and in parallel, compute the descriptors of both images. The learned descriptors are then compared efficiently using the L2 norm and do not require network processing of patch pairs.
Gadot, David, Wolf, Lior
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Unsteady Characteristics of Nonlinear Pressure Loss in a Flow through a Restrictor

Journal of Fluid Science and Technology, 2008
To elucidate the unsteady characteristics of a nonlinear pressure loss generated in a restricted flow, pressure drops across and flow rates through an orifice were precisely measured in sinusoidally oscillating oil flows.
Seiichi WASHIO, Huiqing CHEN, Satoshi TAKAHASHI   +2 more
doaj   +1 more source

Flow distortion and signal loss in spiral imaging [PDF]

Magnetic Resonance in Medicine, 1999
The effect of in-plane motion on the point spread function (velocity PSF) in spiral imaging is studied experimentally and derived mathematically and is shown to consist of a smoothed, trailing edge and fringes around the leading edge. The velocity PSF remains largely in phase with the static PSF, consistent with the absence of signal loss by motion ...
P D, Gatehouse, D N, Firmin
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Flow regime transition maps and pressure loss prediction of gas, oil and water three-phase flow in the vertical riser downstream 90° bend using data driven approach

Digital Chemical Engineering
The simultaneous flow of gas, oil & water is frequently encountered in pipelines during upstream petroleum operations. The multiphase flow results in different types of flow patterns based on the flow rates of fluids, physical properties and geometry
Muhammad Waqas Yaqub, Rajashekhar Pendyala   +1 more
doaj   +1 more source

Magnetically controlled mass loss from extrasolar planets in close orbits [PDF]

, 2014
We consider the role magnetic fields play in guiding and controlling mass-loss via evaporative outflows from exoplanets that experience UV irradiation. First we present analytic results that account for planetary and stellar magnetic fields, along with ...
Adams, Fred C., Owen, James E.
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source