Results 111 to 120 of about 3,047,500 (291)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Review of measurement and testing problems [PDF]
, 1976 Good instrumentation was required to obtain reliable and repeatable baseline data. Problems that were encountered in developing such a total system were: (1) accurate airflow measurement, (2) precise fuel flow measurement, and (3) the instrumentation ...
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Comparison of Zephir and Windcube measurements in the same complex flowfield [PDF]
, 2011 Offshore wind is the major growth area in the wind industry sector today. However, there remains a key, fundamental missing element - a thorough understanding of the offshore wind climatology and likely wind resource.
Fabre, Sylvie +2 more
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Transcutaneous measurement of volume blood flow [PDF]
Blood flow velocity measurements, using Doppler velocimeter, are described. The ability to measure blood velocity using ultrasound is derived from the Doppler effect; the change in frequency which occurs when sound is reflected or transmitted from a ...
Daigle, R. E. +4 more
core +1 more source
, 2016 The magnetic flow meter is one of the best possible choice for the measurement of flow rate of liquid metals in fast breeder reactors. Due to the associated complexities in the measuring environment, theoretical evaluation of their sensitivity is always ...
Kumar, Udaya, S, Sethupathy
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Flow direction measurement criteria and techniques planned for the 40- by 80-/80- x 120-foot wind tunnel integrated systems tests [PDF]
A study was performed in order to develop the criteria for the selection of flow direction indicators for use in the Integrated Systems Tests (ISTs) of the 40 by 80/80 by 120 Foot Wind Tunnel System.
Hoffmann, J. +2 more
core +1 more source