Results 121 to 130 of about 1,047,729 (258)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A Time-of-Flight Extraction Method Based on Time-Sequenced Pulses for Ultrasonic Flow Measurement Using an FPGA-Based Time-to-Digital Converter. [PDF]

Sensors (Basel)
Fan E, Xie T, Wu F.
europepmc   +1 more source

Thermodilution-derived volumetric resting coronary blood flow measurement in humans. [PDF]

EuroIntervention, 2021
Gallinoro E, Candreva A, Colaiori I, Kodeboina M, Fournier S, Nelis O, Di Gioia G, Sonck J, van 't Veer M, Pijls NHJ, Collet C, De Bruyne B.   +11 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Redefining flow measurement in centrifugal pump: the case for RPM and power consumption-based estimation. [PDF]

J Extra Corpor Technol
Condello I.
europepmc   +1 more source

Feasibility of Renal Blood Flow Measurement Using ⁶⁴Cu-ATSM PET/MRI: A Quantitative PET and MRI Study. [PDF]

Diagnostics (Basel), 2023
Nishikawa Y, Takahashi N, Nishikawa S, Shimamoto Y, Nishimori K, Kobayashi M, Kimura H, Tsujikawa T, Kasuno K, Mori T, Kiyono Y, Okazawa H, Iwano M.   +12 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Characterization of a fiber-coupled SPAD camera system for deep-tissue blood-flow measurement using diffuse correlation spectroscopy. [PDF]

Biomed Opt Express
Moore CH, Wayne MA, Ulku AC, Mos P, Bruschini C, Charbon E, Sunar U.   +6 more
europepmc   +1 more source

Glaucoma Diagnostic Performance of Retinal Blood Flow Measurement With Doppler Optical Coherence Tomography. [PDF]

Transl Vis Sci Technol, 2022
Abe T, Yoshioka T, Song Y, Tani T, Kawai M, Omae T, Takahashi K, Takizawa Y, Ro-Mase T, Ishiko S, Minamide K, Sakai J, Akiba M, Hashimoto Y, Yoshida A.   +14 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source