Results 101 to 110 of about 3,047,500 (291)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
In situ lunar heat flow experiment using the LUNAR-A penetrator [PDF]
, 2001 An in situ lunar heat flow measurement is planned using the Japanese Lunar-A penetrators.
Fujimura, A. +5 more
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Measurement of vortex flow fields [PDF]
A 3-D laser fluorescence anemometer (LFA) was designed, built, and demonstrated for use in the Langley 16 x 24 inch Water Tunnel. Innovative optical design flexibility combined with compact and portable data acquisition and control systems were ...
Ambur, Todd A. +3 more
core +1 more source
Characterizing flows with an instrumented particle measuring Lagrangian accelerations
, 2012 We present in this article a novel Lagrangian measurement technique: an instrumented particle which continuously transmits the force/acceleration acting on it as it is advected in a flow. We develop signal processing methods to extract information on the
Gasteuil Y +12 more
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Flow characteristics of a round jet with divergent and convergent tapered annulus
Nihon Kikai Gakkai ronbunshu, 2014 The flow characteristics of round air jets with tapered annulus was investigated experimentally. The divergent and convergent tapered annulus was installed concentrically inside of the round nozzle.
Taichi USUZAWA +2 more
doaj +1 more source
Minimally destructive, Doppler measurement of a quantized, superfluid flow
, 2016 The Doppler effect, the shift in the frequency of sound due to motion, is present in both classical gases and quantum superfluids. Here, we perform an in-situ, minimally destructive measurement, of the persistent current in a ring-shaped, superfluid Bose-
Anderson, N. +5 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source