Results 61 to 70 of about 1,047,729 (258)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

An Overview of Computational Fluid Dynamics as a Tool to Support Ultrasonic Flow Measurements

open access: yesMetrology
Ultrasonic flow meters (UFMs) by transit time are ubiquitous in industrial applications, mainly for their versatility and practicality. They are widely used in gas and liquid installations, such as the oil and gas industry or feedwater systems in nuclear
Guilherme Siqueira de Aquino   +3 more
doaj   +1 more source

An Experimental Study of the Effect of a Baffle on the Flow Structure in a Rectangular Open Channel Using UVP

open access: yesJournal of Fluid Science and Technology, 2010
A flow structure around an intermediate standing baffle in a rectangular open channel has been investigated experimentally. The instantaneous vertical velocity components were successfully measured using an Ultrasonic Velocity Profiler (UVP).
Hamidreza JAMSHIDNIA, Yasushi TAKEDA
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Free Flow and Discharge Characteristics of Trapezoidal-Shaped Weirs

open access: yesFluids, 2020
A number of studies have considered the effects of weir design variations on the free- and submerged-flow characteristics of trapezoidal broad-crested weirs. It appears that the hydraulics of short-crested weir flows have received little attention; thus,
Yebegaeshet T. Zerihun
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Experimental Investigation of Aerodynamic Noise Generated by a Train-Car Gap

open access: yesJournal of Fluid Science and Technology, 2007
To investigate the mechanism of noise generation by a train-car gap, which is one of a major source of noise in Shinkansen trains, experiments were carried out in a wind tunnel using a 1/5-scale model train.
Fumio MIZUSHIMA   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

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