Results 91 to 100 of about 2,192,114 (314)

Minimum‐Peak‐Cost Flows Over Time

open access: yesNetworks
ABSTRACT Peak cost is a novel objective for flows over time that describes the amount of workforce necessary to run a system. We focus on minimizing peak costs in the context of maximum temporally repeated flows and formulate the corresponding MPC‐MTRF problem.
Mariia Anapolska   +7 more
openaire   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Large-Eddy simulation of pulsatile blood flow [PDF]

open access: yes, 2009
Large-Eddy simulation (LES) is performed to study pulsatile blood flow through a 3D model of arterial stenosis. The model is chosen as a simple channel with a biological type stenosis formed on the top wall.
Molla, M.M., Roditi, G., Paul, M.C.
core   +1 more source

Data supporting "Seasonal flow types of glaciers in Sermilik Fjord, Greenland, over 2016-2021"

open access: yes, 2022
Greenland glaciers have three primary seasonal ice flow patterns, or “types:” terminus driven, runoff driven, and runoff adapting. To date, glacier types have been identified by analyzing flow at a single location near the terminus; information at all ...
Poinar, Kristin
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Two-phase flow patterns in turbulent flow through a dose diffusion pipe

open access: yes, 2005
A numerical investigation is carried out for turbulent particle-laden flow through a dose diffusion pipe for a model reactor system. A Lagrangian Stochastic Monte-Carlo particle-tracking approach and the averaged Reynolds equations with a k-e turbulence ...
Tang, H   +5 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

An experimental analysis of fluid structure interaction on a flexible hydrofoil in various flow regimes including cavitating flow [PDF]

open access: yes, 2012
The authors gratefully acknowledge the technical staff of IRENav for its contribution to the experimental set up.The structural response of a rectangular cantilevered flexible hydrofoil submitted to various flow regimes is analyzed through an original ...
SIGRIST, Jean-François   +2 more
core   +1 more source

Transient Behaviour of Natural Convection in a Reservoir Model Induced by Surface Heating

open access: yesJournal of Thermal Science and Technology, 2012
We perform detailed numerical simulations of natural convection in a reservoir model induced by surface heating. The transient behaviour of the flow, including streamlines, isotherms, surface velocity profiles, volumetric flow rates, heat transfer rates,
Peng YU   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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