Results 91 to 100 of about 1,670,401 (308)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Congestion control mechanisms and the best effort service model [PDF]

open access: yes, 2001
In the last few years there has been considerable research toward extending the Internet architecture to provide quality of service guarantees for the emerging real-time multimedia applications. QoS provision is a rather controversial endeavour.
Kirstein, P   +11 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The dynamic interaction of order flows and the CAD/USD exchange rate [PDF]

open access: yes
We explore the relationship between disaggregated order flow, the Canada/U.S. dollar (CAD/USD) market and U.S. macroeconomic announcements. Three types of CAD order flow and the CAD/USD are cointegrated.
Christopher J. Neely, Nikola Gradojevic
core  

Dynamic Flow Rate Control for Vanadium Redox Flow Batteries

open access: yesEnergy Procedia, 2017
Abstract The vanadium redox flow battery (VRB) is one of the most promising technologies for large-scale energy storage. The control of the electrolyte flow rate during its operation has significant impacts on the overall efficiency of the storage system. Although flow-rate optimization under constant current conditions has been addressed in previous
Jiahui Fu   +4 more
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Exchange Rate Dynamics, Intervention and Regime Shifts in China: A Market Microstructure Analysis [PDF]

open access: yes, 2013
This thesis applies the market microstructure approach to investigate exchange rate dynamics, intervention and regime shifts in China’s exchange rate system.
ZHANG, WENTING
core  

Precise Control of Micropipette Flow Rate for Fluorescence Imaging in In Vivo Micromanipulation

open access: yesSensors
Precise regulation of micropipette outlet flow is critical for fluorescence imaging in vivo micromanipulations. In such procedures, a micropipette with a micro-sized opening is driven by gas pressure to deliver internal solution into the in vivo ...
Ruimin Li   +7 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Customer flow, intermediaries, and the discovery of the equilibrium riskfree rate [PDF]

open access: yes, 2008
Macro announcements change the equilibrium riskfree rate. We find that treasury prices reflect part of the impact instantaneously, but intermediaries rely on their customer order flow in the 15 minutes after the announcement to discover the full impact ...
Menkveld, Albert J.   +3 more
core  

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