Results 131 to 140 of about 1,670,401 (308)

Proportional controller for flow rate [PDF]

open access: yesBiotechnology and Bioengineering, 1972
openaire   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Predictive Control of Flow Rates and Concentrations in Sewage Networks

open access: yes
We design a predictive flow rate and concentration controller for wastewater transport and treatment networks. It manages flow rates to avoid overflows during times of high flow, and maximizes treatment efficiency when the system is within capacity limits.
Tan, Shuyao   +5 more
openaire   +3 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Experimental Study on Targeted Flow Rate in Gas-liquid Two Phases Flow during MFC Drilling Operation

open access: yesShiyou jixie, 2016
To address the drilling issues of the deep well with narrow density window like blowout and lost circulation, a micro-flow control (MFC) drilling choke simulation system has been developed, the choke manifold skid and the electro-hydraulic control system
He Long   +5 more
doaj  

Phenomenological characterization and effect of reaction rate of coaxial reaction flow

open access: yes河南理工大学学报. 自然科学版
ObjectivesFor precise control of the coaxial reaction flow process, the macroscopic phenomenological characterization method and control law of reaction rate,Methodsthe cross-linking process of calcium alginate hydrogel hollow fiber was observed online ...
LI Yu   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Heating System Water Flow Rate Prediction Using Three Port Control Valves

open access: yes, 2002
This work highlights the requirement for flow rate measurement in order to monitor energy use in heating systems. It recognises that not all heating systems have the facility to monitor system water flow rates.
Underwood, Chris, Edge, Jerry
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

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