Results 171 to 180 of about 1,670,401 (308)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Studies in transonic flow

open access: yes, 1983
This thesis is divided into, two distinct parts. Part I describes the design and development of an intermittent cryogenic wind-tunnel, in which the cold conditions are generated by the expansion of high pressure gas.
Mohan, S. R.
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

A Virtual EXV Mass Flow Sensor for Applications With Two-Phase Flow Inlet Conditions

open access: yes, 2012
In conventional vapor compression systems, electronic expansion valves (EXVs) are used for refrigerant flow control. Subcooled refrigerant enters the expansion device and is expanded to the evaporation pressure while the valve opening is modified to ...
Groll, Eckhard A.   +2 more
core  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Control of Powder Flow Rate in Laser Metal Deposition Process

open access: yes, 2004
Precise regulation of powder flow in laser based manufacturing processes is critical to achieving excellent part quality. Control of powder flow in laser based manufacturing processes is challenging since low flow rates, where nonlinear effects are ...
Thayalan, Vishnu, Landers, Robert G.
core  

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