Results 41 to 50 of about 933,177 (266)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
EnergiesThe Helically Coiled Heat Exchanger (HCHX) is a promising candidate for modular Molten Salt Reactors (MSRs), valued for its high heat transfer efficiency, structural compactness, reduced fouling tendency, and excellent thermal compensation capabilities ...
Yu Wang, Qi-Ming Li, Yang Zou
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Research on Application Status of Water-cooled Radiator of Rail Transit
机车电传动, 2020 A variety of different structures of water-cooled radiators used in rail transportation were tested and compared. The effects of different types of flow channels on the flow resistance and heat dissipation performance of radiators were compared, and the ...
Xiong WANG +4 more
doaj
FLOW RESISTANCE OF STEPPED CHANNEL FLOWS
PROCEEDINGS OF HYDRAULIC ENGINEERING, 2000 Many researchers have investigated the friction factor of stepped channel flows, but general agreement has not been obtained. Because a method for evaluating a supercritical depth of the stepped channel flow might not be established. Further, the hydraulic condition required to form a quasi-uniform flow on the steppedchannel has not been clarified ...
YASUDA, Youichi +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Flow resistance to resistance ratios in cubic graphs
Discrete Applied MathematicszbMATH Open Web Interface contents unavailable due to conflicting licenses.
Imran Allie +2 more
openaire +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source