Results 111 to 120 of about 8,749,784 (346)
Study on the fluid flow rule of five-cylinder plunger pump hydraulic end
Petroleum, 2018 The change of velocity and pressure of flow field in suction and discharge chamber of five-cylinder plunger pump obtained by CFD under maximum and minimum stroke, the results show that: when the stroke is 79 rpm, the internal of pump head will produce ...
Zhanghua Lian +5 more
doaj +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Optimization of Continuous Flow-Shop Scheduling Considering Due Dates
AlgorithmsFor a no-wait flow shop with continuous-flow characteristics, this study simultaneously considers machine setup times and rated processing speed constraints, aiming to minimize the sum of the maximum completion time and the maximum tardiness.
Feifeng Zheng, Chunyao Zhang, Ming Liu
doaj +1 more source
Metals, 2018 Magnesium sheet metal alloys have a hexagonal close packed (hcp) crystal structure that leads to severe evolving anisotropy and tension-compression asymmetry as a result of the activation of different deformation mechanisms (slip and twinning) that are ...
Armin Abedini +2 more
doaj +1 more source
Self-Organizing Traffic at a Malfunctioning Intersection [PDF]
Traffic signals and traffic flow models have been studied extensively in the past and have provided valuable insights on the design of signalling systems, congestion control, and punitive policies. This paper takes a slightly different tack and describes
Sugata Mitra, Sujai Kumar
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Pension Liabilities: Fear Tactics and Serious Policy [PDF]
This working paper argues that pension funds should adopt a funding principle that is consistent with a return on holdings conditional on the state of the stock market.
David Rosnick, Dean Baker
core
Frozen shuffle update for an asymmetric exclusion process on a ring
, 2011 We introduce a new rule of motion for a totally asymmetric exclusion process (TASEP) representing pedestrian traffic on a lattice. Its characteristic feature is that the positions of the pedestrians, modeled as hard-core particles, are updated in a fixed
Appert-Rolland C Cividini J Hilhorst H J +15 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source