Results 81 to 90 of about 308,255 (264)
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Rule of six as a Predictor of Arteriovenous Fistula
Arcades of MedicineArteriovenous fistula (AVF) is the recommended vascular access for hemodialysis in end-stage renal disease (ESRD) due to superior longevity and fewer complications compared with grafts or catheters.
Ibrahim Hegazy +2 more
doaj +1 more source
Discrete Dynamics in Nature and Society, 2017 Stranding too many passengers at the stations will reduce the service level; if measures are not taken, it may lead to serious security problems. Deeply mining the time distribution mechanism of passenger flow will guide the operation enterprises to make
Xiaobing Ding +3 more
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On flow rules in plastic deformation
, 1991 Summary: The purpose of the present paper is to compare some consquences of the classical flow-rule of plasticity due to Levy and Mises with those of the flow equation recently proposed by \textit{R. N. Dubey} and \textit{S. Bedi} [Proc. Adv. Plast., pp. 291-295 (1989)].
Dubey, R., Bedi, S.
openaire +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Optimization of Continuous Flow-Shop Scheduling Considering Due Dates
AlgorithmsFor a no-wait flow shop with continuous-flow characteristics, this study simultaneously considers machine setup times and rated processing speed constraints, aiming to minimize the sum of the maximum completion time and the maximum tardiness.
Feifeng Zheng, Chunyao Zhang, Ming Liu
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Intermittent Debris Flow and Its Activity Rule
Shuitu baochi yanjiu, 2005 Intermittent debris flow is the most important moving form of viscous debris flows.According to field observation materials of debris flow along Jiangjia ravine between 1987 and 1994,50 times typical debris flows with whole occurring process,obvious ...
doaj