Results 81 to 90 of about 295,706 (263)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Rule of six as a Predictor of Arteriovenous Fistula

Arcades of Medicine
Arteriovenous fistula (AVF) is the recommended vascular access for hemodialysis in end-stage renal disease (ESRD) due to superior longevity and fewer complications compared with grafts or catheters.
Ibrahim Hegazy, Ayman Salem, Khaled Shawky   +2 more
doaj   +1 more source

The Aggregation Mechanism Mining of Passengers’ Flow with Period Distribution Based on Suburban Rail Lines

Discrete Dynamics in Nature and Society, 2017
Stranding too many passengers at the stations will reduce the service level; if measures are not taken, it may lead to serious security problems. Deeply mining the time distribution mechanism of passenger flow will guide the operation enterprises to make
Xiaobing Ding, Hua Hu, Zhigang Liu, Haiyan Zhu   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Optimization of Continuous Flow-Shop Scheduling Considering Due Dates

Algorithms
For a no-wait flow shop with continuous-flow characteristics, this study simultaneously considers machine setup times and rated processing speed constraints, aiming to minimize the sum of the maximum completion time and the maximum tardiness.
Feifeng Zheng, Chunyao Zhang, Ming Liu
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Analysis of the flow field characteristics of a centrifugal blood pump in a heartbeat cycle

Advances in Mechanical Engineering
Blood pumps are medical devices that can temporarily or permanently replace the heart to perform the job of blood pumping. To study the internal flow field characteristics of the centrifugal blood pump, high-speed photography (HSP) images of the internal
Jiahui Zhang, Fan Yang, Chunlei Shao
doaj   +1 more source

Criteria and rules for privacy management prior to self-disclosures on social network sites (SNSs)

Cyberpsychology: Journal of Psychosocial Research on Cyberpspace
This study applied a novel theoretical framework of communication privacy management theory (CPM) to examine how criteria such as context, culture, and privacy motivation influence information boundary coordination rules (boundary linkage, ownership ...
SoeYoon Choi
doaj   +1 more source