Results 131 to 140 of about 1,835,674 (303)

In-flight flow visualization with pressure measurements at low speeds on the NASA F-18 high alpha research vehicle [PDF]

open access: yes
In-flight results from surface and off-surface flow visualizations and from extensive pressure distributions document the vortical flow on the leading edge extensions (LEX) and forebody of the NASA F-18 high alpha research vehicle for low speeds and ...
Delfrate, John H.   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Numerical solutions of atmospheric flow over semielliptical simulated hills [PDF]

open access: yes
Atmospheric motion over obstacles on plane surfaces to compute simulated wind fields over terrain features was studied. Semielliptical, two dimensional geometry and numerical simulation of flow over rectangular geometries is also discussed.
Frost, W., Shieh, C. F.
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Numerical Simulation and Experimental Study on the Aerodynamics of Propulsive Wing for a Novel Electric Vertical Take-Off and Landing Aircraft

open access: yesAerospace
The electric vertical take-off and landing (eVTOL) aircraft offers the advantages of vertical take-off and landing, environmental cleanliness, and automated control, making it a crucial component of future urban air traffic.
Junjie Wang   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Control of vortical separation on conical bodies [PDF]

open access: yes
In a variety of aeronautical applications, the flow around conical bodies at incidence is of interest. Such applications include, but are not limited to, highly maneuverable aircraft with delta wings, the aerospace plane and nose portions of spike inlets.
Mourtos, Nikos J., Roberts, Leonard
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Interpretable GBDT model-based multi-objective optimization analysis for the lateral inlet/outlet design in pumped-storage power stations

open access: yesJournal of Hydroinformatics
The uneven velocity distribution formed at the lateral inlet/outlet poses a significant risk of damaging the trash racks. Reasonable design of the inlet/outlet structures requires the consideration of two major aspects: the average velocity (Vm) and the ...
Ganggui Guo   +4 more
doaj   +1 more source

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