Results 151 to 160 of about 598,432 (318)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Active flow control systems architectures for civil transport aircraft

, 2010
Copyright @ 2010 American Institute of Aeronautics and AstronauticsThis paper considers the effect of choice of actuator technology and associated power systems architecture on the mass cost and power consumption of implementing active flow control ...
Crowther, W. J.; id_orcid, Liddle, S. C., W. J. Crowther, Jabbal, M, Liddle, SC, S. C. Liddle, Liddle, Stephen, Jabbal, M., Crowther, WJ, M. Jabbal   +9 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The Flow Field Characteristics and Separation Performance of the Compact Series Gas–Liquid Separator

Digitalization is leading the development direction of oilfields in the future. And the precise measurement of produced fluids is the core component supporting the construction of digital oilfields.
Sheng Gao, Lei Xing, Jingfu Wang, Ruijie Zhang, Yueyao Liu   +4 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Unsteady separation past moving surfaces

, 1998
Unsteady boundary-layer development over moving walls in the limit of infinite Reynolds number is investigated using both the Eulerian and Lagrangian formulations.
Degani, AT, Smith, FT, Walker, JDA
core  

Comparisons of Membrane Fouling and Separation Efficiency in Protein/Polysaccharide Cross-Flow Microfiltration using Membranes with Different Morphologies

, 2014
The membrane fouling and filtration performance of Bovine serum albumin (BSA)/dextran cross-flow microfiltration using membranes with different morphologies are analyzed and compared. Three 0.1 μm hydrophilic membranes made of mixed cellulose ester (MCE),
Hwang, Kuo-Jen, Hwang, Kuo-jen; Chiang, Yuan-chun   +1 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Study on Separation of Phycoerythrin by Q-Sepharose Fast Flow

, 2012
This study aimed to establish an efficient process for separation of phycoerythrin by using Q Sepharose Fast Flow resin and verify its feasibility.[Method] Elution gradient,loading volume and flow rate were optimized to determine the optimal separation ...
Gao M(高敏), Wang CQ(王翠芹), Zhang Y(张轶), Gu M(顾铭), Wang ZH(王长海), Zhang B(张彬)   +5 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source