Results 41 to 50 of about 85,049 (338)

The Complexity of Mean Flow Time Scheduling Problems with Release Times

open access: yes, 2006
We study the problem of preemptive scheduling n jobs with given release times on m identical parallel machines. The objective is to minimize the average flow time.
Baptiste, Philippe   +5 more
core   +3 more sources

A decomposition based algorithm for flexible flow shop scheduling with machine breakdown [PDF]

open access: yes, 2009
Research on flow shop scheduling generally ignores uncertainties in real-world production because of the inherent difficulties of the problem. Scheduling problems with stochastic machine breakdown are difficult to solve optimally by a single approach ...
Choi, SH, Wang, K
core   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

open access: yesFEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac   +3 more
wiley   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Robust multi-objective hybrid flow shop scheduling

open access: yesJournal of Applied Research on Industrial Engineering, 2021
Scheduling is an important decision-making process that aims to allocate limited resources to the jobs in a production process. Among scheduling problems, Hybrid Flow Shop (HFS) scheduling has good adaptability with most real world applications including
Behnaz Zanjani   +3 more
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Flexible flow shop scheduling with stochastic processing times: A decomposition-based approach [PDF]

open access: yes, 2012
Flexible flow shop scheduling problems are NP-hard and tend to become more complex when stochastic uncertainties are taken into consideration. Although some methods have been developed to address such problems, they remain inherently difficult to solve ...
Choi, SH, Wang, K
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

A novel hybrid genetic algorithm to solve the make-to-order sequence-dependent flow-shop scheduling problem [PDF]

open access: yes, 2014
Flow-shop scheduling problem (FSP) deals with the scheduling of a set of n jobs that visit a set of m machines in the same order. As the FSP is NP-hard, there is no efficient algorithm to reach the optimal solution of the problem. To minimize the holding,
Ghomi, S.M.T. Fatemi   +2 more
core   +1 more source

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

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