Results 51 to 60 of about 6,312 (313)

Multi-Objective Parallel Variable Neighborhood Search for Energy Consumption Scheduling in Blocking Flow Shops

IEEE Access, 2018
Blocking flow shop scheduling problem has been extensively studied because of its widespread industrial applications. However, the existing research mostly aims at makespan or total flow time minimization and ignores the criterion for energy saving. This
Fucai Wang, Guanlong Deng, Tianhua Jiang, Shuning Zhang   +3 more
doaj   +1 more source

Scheduling stochastic two-machine flow shop problems to minimize expected makespan [PDF]

Decision Science Letters, 2013
During the past few years, despite tremendous contribution on deterministic flow shop problem, there are only limited number of works dedicated on stochastic cases.
Mehdi Heydari, Mohammad Mahdavi Mazdeh, Mohammad Bayat   +2 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

No idle flow shop scheduling models for optimization of machine rental costs with processing and separated setup times

Frontiers in Applied Mathematics and Statistics
Scheduling is one of the many skills required for advancement in today’s modern industry. The flow-shop scheduling problem is a well-known combinatorial optimization challenge. Scheduling issues for flow shops are NP-hard and challenging.
Shakuntla Singla, Harshleen Kaur, Deepak Gupta, Umar Muhammad Modibbo, Jatinder Kaur   +4 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Simultaneous Worker Assignment and Scheduling Problem to Minimize Makespan in Flexible Flow Shop via Metaheuristic Approaches [PDF]

International Journal of Industrial Engineering and Production Research, 2019
In many real scheduling situations, it is necessary to deal with the worker assignment and job scheduling together. However, in traditional scheduling problems, only the machine is assumed to be a constraint and there isn’t any constraint about workers ...
Ebrahim Asadi-Gangraj, Fatemeh Bozorgnezhad, Mohammad Mahdi Paydar   +2 more
doaj   +1 more source

A cooperative adaptive genetic algorithm for reentrant hybrid flow shop scheduling with sequence-dependent setup time and limited buffers [PDF]

, 2023
Qianqian Zheng, Yu Zhang, Hongwei Tian, Lijun He   +3 more
openalex   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source