Results 71 to 80 of about 6,312 (313)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Flow shop scheduling decisions through Techniques for Order Preference by Similarity to an Ideal Solution (TOPSIS)

International Journal of Production Management and Engineering, 2016
The flow-shop scheduling problem (FSP) has been widely studied in the literature and having a very active research area. Over the last few decades, a number of heuristic/meta-heuristic solution techniques have been developed.
Arun Gupta, Shailendra Kumar
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

A computational efficient optimization of flow shop scheduling problems. [PDF]

Sci Rep, 2022
Liang Z, Zhong P, Liu M, Zhang C, Zhang Z.   +4 more
europepmc   +1 more source

Parallel Path-Relinking Method for the Flow Shop Scheduling Problem [PDF]

, 2008
Wojciech Bożejko, Mieczysław Wodecki
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A novel fuzzy model for multi-objective permutation flow shop scheduling problem with fuzzy processing time

Advances in Mechanical Engineering, 2019
This article proposes a novel fuzzy model for solving fuzzy multi-objective permutation flow shop scheduling problem with fuzzy processing time. Specifically, two fuzzy objectives, that is, the fuzzy makespan and the fuzzy total flow time, are taken into
Fuyu Yuan, Xin Xu, Minghao Yin
doaj   +1 more source

A Heuristic-Based Adaptive Iterated Greedy Algorithm for Lot-Streaming Hybrid Flow Shop Scheduling Problem with Consistent and Intermingled Sub-Lots. [PDF]

Sensors (Basel), 2023
Lu Y, Tang Q, Pan Q, Zhao L, Zhu Y.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Energy-efficient distributed heterogeneous re-entrant hybrid flow shop scheduling problem with sequence dependent setup times considering factory eligibility constraints. [PDF]

Sci Rep, 2022
Geng K, Liu L, Wu Z.
europepmc   +1 more source