Results 41 to 50 of about 6,048,963 (333)

Friction law and hysteresis in granular materials

, 2017
The macroscopic friction of particulate materials often weakens as the flow rate is increased, leading to potentially disastrous intermittent phenomena including earthquakes and landslides. We theoretically and numerically study this phenomenon in simple
DeGiuli, E., Wyart, M.
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Experimental Investigation on Failure Modes and Progressive Failure Process of Earthen Check Dam Triggered by Upstream Flow

Frontiers in Earth Science, 2022
The progressive failure of earthen check dams triggered by upstream flow is common in loess gullies on the Loess Plateau of China. However, studies on the formation mechanism of progressive failure are still unclear.
Yanbo Zhu, Futong Li, Fanfan Yang, Yuxuan Zhang, Wanghui Tian, Hengxing Lan, Hengxing Lan   +6 more
doaj   +1 more source

Inferring spatial and signaling relationships between cells from single cell transcriptomic data. [PDF]

, 2020
Single-cell RNA sequencing (scRNA-seq) provides details for individual cells; however, crucial spatial information is often lost. We present SpaOTsc, a method relying on structured optimal transport to recover spatial properties of scRNA-seq data by ...
Cang, Zixuan, Nie, Qing
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Micro-mechanism analysis of Zhongchuan loess liquefaction disaster induced by Jishishan M6.2 earthquake in 2023

Open Geosciences
On December 18, 2023, the M S 6.2 Jishishan earthquake triggered a large-scale liquefaction disaster of loess sites in Jintian and Caotan villages, Zhongchuan town, Minhe County, Haidong City, Qinghai Province.
Wang Yi, Wang Qian, Zhang Wuyu, Zhong Xiumei, Liu Fuqiang, Jia Shichao, Hu Xuefeng   +6 more
doaj   +1 more source

Calculation of the total cross-sectional area of the spool air of the distributor of an automobile air motor

Вісник Харківського національного університету імені В.Н. Каразіна. Серія: Математичне моделювання, інформаційні технології, автоматизовані системи управління, 2019
One of actual issues in the field of gas dynamics of piston engines which concerns the analytical estimation of influence of structural and regime parameters on the processes of flowing of gases through gas distribution mechanisms is examined.
Oleksandr I. Voronkov, Volodymyr M. Kolodiazhnyi, Olga Y. Lisina, Ihor M. Nikitchenko   +3 more
doaj   +1 more source

A mesoscopic model for the rheology of soft amorphous solids, with application to mi- crochannel flows

, 2013
We study a mesoscopic model for the flow of amorphous solids. The model is based on the key features identified at the microscopic level, namely peri- ods of elastic deformation interspersed with localised rearrangements of parti- cles that induce long ...
Barrat, Jean-Louis, Nicolas, Alexandre
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Study on Steady Flow Force of a Bidirectional Throttling Slide Valve and Its Compensation Optimization

Applied Sciences
This paper focuses on a typical pressure-controlled slide valve, utilizing momentum analysis and computational fluid dynamics to simulate and analyze the asymmetry of steady flow force curves under bidirectional throttling patterns.
Qi Mao, Xinying Jia, Zhe Liu, Guang Li, Yichi Cao, Qingjun Yang   +5 more
doaj   +1 more source