Results 41 to 50 of about 898,092 (267)

Treatment Decision‐Making Roles and Preferences Among Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Decision‐making (DM) dynamics between adolescents and young adults (AYAs) with cancer, parents, and oncologists remain underexplored in diverse populations. We examined cancer treatment DM preferences among an ethnically and socioeconomically diverse group of AYAs and their parents.
Amanda M. Gutierrez, Jill O. Robinson, Wendy A. Allen‐Rhoades, Hadley S. Smith, Isabel Canfield, Rebecca L. Hsu, Sarah R. Scollon, Lauren R. Desrosiers‐Battu, Nicole M. Schneider, Frank Y. Lin, Donald Williams Parsons, Sharon E. Plon, Mary A. Majumder, Janet Malek, Amy L. McGuire   +14 more
wiley   +1 more source

Flow behavior and BP neural network high temperature constitutive model of Ti-22Al-24Nb-0.5Y alloy

Cailiao gongcheng, 2019
Isothermal constant strain thermal compression test was carried out by Gleeble-3500 thermal simulation test machine. Based on the experimental data, the flow behavior of Ti-22Al-24Nb-0.5Y alloy was studied.
ZHOU Feng, WANG Ke-lu, LU Shi-qiang, WAN Peng, CHEN Xu-huai   +4 more
doaj   +1 more source

Prediction of high-temperature flow stress of HMn64–8–5–1.5 manganese brass alloy based on modified Zerilli-Armstrong, Arrhenius and GWO-BPNN model

Materials Research Express, 2022
An accurate constitutive model is essential for designing the process of hot precision forging and numerical simulation. Based on the isothermal compression tests of as-extruded HMn64–8–5–15 manganese brass alloy at the deformation temperature of 873 ...
Qiang Liang, Xianming Zhang, Xin Liu, Yongliang Li   +3 more
doaj   +1 more source

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano, Alexander Yelak, Walid Kaadan, Shlomo Caduri, Rivka Friedland, Orli Michaeli, Gad Dotan, Osnat Konen   +7 more
wiley   +1 more source

Hot deformation of nickel particles reinforced aluminium based composites: flow behaviour, microstructural evolution and processing map analyses

Materials Research Express, 2021
The hot deformation behavior and workability of stir cast Al 6063 alloy reinforced with 6 wt. % Nickel particles was investigated using flow stress-strain plots, microstructural analysis and processing maps.
Kenneth Kanayo Alaneme, Saheed Adeoye Babalola, Michael Oluwatosin Bodunrin, Lesley Heath Chown, Eloho Anita Okotete, Nthabiseng Beauty Maledi   +5 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Microstructure evolution and constitutive analysis of nuclear grade AISI-316H austenitic stainless steel during thermal deformation

Materials Research Express, 2023
Compression experiments were performed on AISI-316H austenitic stainless steel using Gleeble-3800 at temperatures ranging from 900 °C and 1200 °C and strain rates ranging from 0.01 and 10 s ^−1 , up to the actual strain of 0.69.
Jian Huang, Zong-xu Pang, Ji-chun Guan, Liu-qun Fan, Jian-ping Zhang, Dian-dong Sun, Yong Wang   +6 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Flow Stress Behavior of 15%SiC_P/8009 Aluminum Matrix Composite During Hot Compression Deformation

Journal of Aeronautical Materials, 2017
The flow stress behavior of 15%SiCP/8009 aluminum matrix composite at deformation temperature of 400-550 ℃ and strain rate of 0.001-1 s-1 was studied by hot compression testing on the Gleeble-3500 thermal-mechanical simulator.
WANG Yu, TENG Jie, CHEN Shuang, LUO Haibo, TANG Liulian, ZHANG Hui   +5 more
doaj   +1 more source