Results 61 to 70 of about 6,571,449 (244)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Determination of flow stress by the hydraulic bulge test [PDF]

Metalurgija, 2008
In sheet metal forming operations the mechanical properties of the sheet metal (stress-strain curve, flow stress) greatly influence metal flow and product quality.
Slota, J., Spišák, E.
doaj  

Microstructure evolution of TC4 powder by spark plasma sintering after hot deformation

High Temperature Materials and Processes, 2020
The cylindrical samples of TC4 titanium alloy prepared by spark plasma sintering (SPS) were compressed with hot deformation of 70% on the thermosimulation machine of Gleeble-1500.
Yan Jiangpeng, Zhang Zhimin, Xu Jian, Wu Yaojin, Zhao Xi, Xue Yong, Liu Haijun   +6 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Multiparametric flow cytometry and cell sorting for the assessment of viable, injured, and dead bifidobacterium cells during bile salt stress [PDF]

, 2002
Using a flow cytometry-based approach, we assessed the viability of Bifidobacterium lactis DSM 10140 and Bifidobacterium adolescentis DSM 20083 during exposure to bile salt stress.
Breeuwer, P., Vos, W.M., de, Rombouts, F.M., Abee, T., Ben Amor, K., Verbaarschot, P., Akkermans, A.D.L., Amor, K., Ben   +7 more
core  

Lipopolysaccharide, high glucose and saturated fatty acids induce endoplasmic reticulum stress in cultured primary human adipocytes : salicylate alleviates this stress [PDF]

, 2010
Recent findings indicate that endoplasmic reticulum (ER) stress is significantly increased in adipose tissue of obese human subjects and is critical to the initiation and integration of pathways of inflammation and insulin action.
Saif Alhusaini, Harte, A., McGee, K., Gyanendra Tripathi, Kumar, Sudhesh, Tripathi, Gyanendra, Sudhesh Kumar, Alhusaini, S., McTernan, P. G., Harte, A. L., McTernan, P., Bruno Schisano, Philip McTernan, Schisano, B., McGee, K. C., Kumar, S., Alison Harte, Tripathi, G., Kirsty McGee   +18 more
core   +1 more source

Dynamic Recrystallization Behavior of AISI 420 Stainless Steel under Hot Compression

High Temperature Materials and Processes, 2015
Hot deformation behavior of AISI 420 stainless steel was studied under hot compression tests in the temperature range of 950 to 1150 °C and strain rates of 0.01 s−1 and 0.1 s−1.
Cao Y., Di H.S., Misra R.D.K.
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source