Results 81 to 90 of about 942,150 (267)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Study of Flow Stress Models and Ductile Fracture Criteria for CHN327 Nickel-Based Superalloy. [PDF]

Materials (Basel), 2023
Xia Y, Yang W, Yu Y, Teng H, Cheng Q.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Towards an Optimized Artificial Neural Network for Predicting Flow Stress of In718 Alloys at High Temperatures. [PDF]

Materials (Basel), 2023
Zhang C, Shi Q, Wang Y, Qiao J, Tang T, Zhou J, Liang W, Chen G.   +7 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effects of electrical pulse on metal deformation behaviors

Materials Research Express
As a kind of special energy field assisted plastic forming, electric pulse assisted plastic forming combines multiple physical fields, such as thermal, electrical, magnetic and mechanical effects, has multiple effects on metal.
Tao Huang, Fan Yang, Bing-Hui Xing, Ke-Xing Song, Nan Xiang, Yan-Min Zhang, Xue-Wen Chen, Jun-Qing Guo   +7 more
doaj   +1 more source

Forces prediction in micro-grinding single-crystal copper considering the crystallographic orientation

Manufacturing Review, 2018
In the micro-grinding of single-crystal copper, the effect of crystallography becomes significant as the wheel works intra-crystalline. To quantify the effect of crystallographic orientation (CO) related to the cutting direction on the micro-grinding ...
Zhao Man, Ji Xia, Li Beizhi, Liang Steven Y.   +3 more
doaj   +1 more source

Cancer cell viscoelasticity measurement by quantitative phase and flow stress induction. [PDF]

Biophys J, 2022
Vicar T, Chmelik J, Navratil J, Kolar R, Chmelikova L, Cmiel V, Jagos J, Provaznik I, Masarik M, Gumulec J.   +9 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Study on constitutive models of hot deformation for 34CrNi3MoV steel

Metalurgija, 2023
Isothermal constant strain rate compression experiments were conducted on 34CrNi3MoV steel using a thermal simulation experimental machine to study its thermal deformation behavior, with deformation temperatures ranging from 800 - 1 200 °C and strain ...
B. Zheng, D. Xu, Y. Q. Wang, L. X. Guo, H. Y. Zhao, D. Y. Ju   +5 more
doaj