Results 81 to 90 of about 1,040,830 (316)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Haemodynamic responses to heat stress and hypohydration in resting and exercising humans: Implications for the regulation of skeletal muscle blood flow

, 2010
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Heat stress-induced hyperthermia and exercise-induced hypohydration are associated with marked alterations in limb and systemic haemodynamics in humans ...
Pearson, James
core  

NARX Neural Network Model for Describing the Flow Stress of Metallic Materials During High-Temperature Plastic Deformation

Applied Sciences
Accurate prediction of the behavior of alloys and metal matrix composites during high-temperature deformation requires strict consideration of the loading history.
Alexander Smirnov
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Multiparametric flow cytometry and cell sorting for the assessment of viable, injured, and dead bifidobacterium cells during bile salt stress

, 2002
Using a flow cytometry-based approach, we assessed the viability of Bifidobacterium lactis DSM 10140 and Bifidobacterium adolescentis DSM 20083 during exposure to bile salt stress.
Breeuwer, P., Vos, W.M., de, Rombouts, F.M., Abee, T., Ben Amor, K., Verbaarschot, P., Akkermans, A.D.L., Amor, K., Ben   +7 more
core  

Effects of Quasi-Static Strain Rate and Temperature on the Microstructural Features of Post-Processed Microstructures of Laser Powder Bed Fusion Ti6Al4V Alloy

Applied Sciences
This study documents an investigation of the flow stress properties and microstructural features of Ti6Al4V (ELI) alloy produced using laser powder bed fusion (LPBF).
Amos Muiruri, Maina Maringa, Willie du Preez   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Study of a bi-directional axial flow blood pump [PDF]

, 2012
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.A common treatment for circulatory disorders is the application of rotary blood pumps to locally increase blood flow to required levels.
Swalen, Marcel Johannes Petrus
core  

A characterization for the flow behavior of as-extruded 7075 aluminum alloy by the improved Arrhenius model with variable parameters

Materials Research, 2013
In order to perform the numerical simulations of forging response and establish the processing parameters for as-extruded 7075 aluminum alloy, the compressive deformation behavior of as-extruded 7075 aluminum alloy were investigated at the temperatures ...
Guo-zheng Quan, Gui-sheng Li, Yang Wang, Wen-quan Lv, Chun-tang Yu, Jie Zhou   +5 more
doaj  

A Proposal of a Constitutive Description for Aluminium Alloys in Both Cold and Hot Working

Metals, 2016
The most important difficulties when the behaviour of a part that is subjected to external mechanical forces is simulated deal with the determination of both the material thermo-mechanical properties and its boundary conditions.
Javier León, Carmelo J. Luis, Juan P. Fuertes, Ignacio Puertas, Rodrigo Luri, Daniel Salcedo   +5 more
doaj   +1 more source