Thermal Deformation Behavior and Dynamic Softening Mechanisms of Zn-2.0Cu-0.15Ti Alloy: An Investigation of Hot Processing Conditions and Flow Stress Behavior. [PDF]
Materials (Basel), 2023 Xie G +7 more
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Influence of Modification on Flow Stress Behavior and Corrosive Properties of a Hypoeutectic Al-Si Alloy. [PDF]
Materials (Basel), 2022 Du K, Song L, Huang S, Yuan X.
europepmc +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Flow stress stabilization of Zn-Cu-Mn-Mg alloys using thermomechanical processing. [PDF]
Mater Charact, 2022 Ardakani MS, Kampe SL, Drelich JW.
europepmc +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
A Flow Stress Model of 300M Steel for Isothermal Tension. [PDF]
Materials (Basel), 2021 Chen R, Zhang S, Liu X, Feng F.
europepmc +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Deformation Behavior, a Flow Stress Model Considering the Contribution of Strain and Processing Maps in the Isothermal Compression of a Near-α Ti-3.3Al-1.5Zr-1.2Mo-0.6Ni Titanium Alloy. [PDF]
Materials (Basel), 2022 Yu W +5 more
europepmc +1 more source