Results 91 to 100 of about 6,571,449 (244)

Constitutive equations of AA6111 aluminum alloy

open access: yesMetalurgija, 2019
The hot compression test was conducted in Gleeble-1 500D to study the hot flow stress behavior of AA6 111 aluminum alloy belonging to Al-Mg-Si series, at the deformation temperatures ranging from 350 to 500 °C and strain rates ranging from 0,01 s-1 to 1 ...
B. Z. Wang   +5 more
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Mechanism of Electropulsing Treatment Technology for Flow Stress of Metal Material: A Review

open access: yesAlloys
Residual stress is caused by non–uniform deformation caused by non–uniform force, heat and composition, which is of great significance in engineering applications.
Bobo Lu   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Enhanced tensile plasticity of Zr based bulk metallic glasses by a stress induced large scale flow

open access: yes, 2017
Tensile plasticity in a Zr-based bulk metallic glasses is achieved through a stress induced large-scale flow. The large-scale flow is activated in a complex stress field which is produced by introducing micro-pits array on specimen surfaces using a ...
Huan, Y (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China.   +6 more
core   +1 more source

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