Results 41 to 50 of about 1,040,830 (316)
The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli +3 more
wiley +1 more source
Determining Material Data for Welding Simulation of Presshardened Steel
Metals, 2018 In automotive body-in-white production, presshardened 22MnB5 steel is the most widely used ultra-high-strength steel grade. Welding is the most important faying technique for this steel type, as other faying technologies often cannot deliver the same ...
Jonny Kaars, Peter Mayr, Kurt Koppe
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi +5 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tandem cylinder flow and noise predictions using a hybrid RANS/LES approach [PDF]
, 2014 The performance of a novel hybrid RANS/LES methodology for accurate flow and noise predictions of the NASA Tandem Cylinder Experiment is investigated.
Sandberg, R. +3 more
core +1 more source
Hot deformation behavior and flow-stress anomaly of 5Cr9Si3 valve steel at elevated temperatures
工程科学学报, 2015 The hot deformation behavior of 5Cr9Si3 valve steel was investigated by hot working simulation test at different hot working parameters. When the deformation temperature increases from 850 to 900℃ or from 1000 to 1100℃, the peak stress decreases; but ...
WU Yun-sheng +4 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Modification of the lithospheric stress field by lateral variations in plate-mantle coupling [PDF]
, 2009 The presence of deeply penetrating continental roots may locally increase the magnitude of basal shear tractions by up to a factor of 4 compared to a layered viscosity structure.
Naliboff, JB +5 more
core +1 more source
Flow behavior and BP neural network high temperature constitutive model of Ti-22Al-24Nb-0.5Y alloy
Cailiao gongcheng, 2019 Isothermal constant strain thermal compression test was carried out by Gleeble-3500 thermal simulation test machine. Based on the experimental data, the flow behavior of Ti-22Al-24Nb-0.5Y alloy was studied.
ZHOU Feng +4 more
doaj +1 more source