Results 141 to 150 of about 1,249,001 (308)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Aerodynamic noise research support Quarterly progress report, Jan. - Mar. 1966 [PDF]

open access: yes
Aerodynamic noise research - acoustic environment due to separated flows and oscillating shocks and flow visualization experiments with supersonic separated turbulent ...
Lowson, M. V.
core   +2 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

Flow Visualization [PDF]

open access: yesJournal of Fluids Engineering, 1980
Tsuyoshi Asanuma, Richard A. Bajura
openaire   +2 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Boundary layer flow visualization for flight testing [PDF]

open access: yes
Flow visualization is used extensively in flight testing to determine aerodynamic characteristics such as surface flow direction and boundary layer state. Several visualization techniques are available to the aerodynamicist.
Obara, Clifford J.
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

3D Printed Biomodels for Flow Visualization in Stenotic Vessels: An Experimental and Numerical Study. [PDF]

open access: yesMicromachines (Basel), 2020
Carvalho V   +5 more
europepmc   +1 more source

Wing Tip Vortex Drag [PDF]

open access: yes
Optimization of L/D through minimizing induced drag through a detailed flow study together with force, pressure and vorticity measurements is considered.
Muirhead, V. U.
core   +1 more source

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