Results 41 to 50 of about 652,224 (264)

Flow: Statistics, visualization and informatics for flow cytometry [PDF]

Source Code for Biology and Medicine, 2008
Abstract Flow is an open source software application for clinical and experimental researchers to perform exploratory data analysis, clustering and annotation of flow cytometric data. Flow is an extensible system that offers the ease of use commonly found in commercial flow cytometry software packages and the statistical power of
Jacob Frelinger, Thomas B. Kepler, Cliburn Chan   +2 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

VMetaFlow: A Meta-Framework for Integrating Visualizations in Coordinated View Applications

IEEE Access, 2022
The analysis and exploration of complex data sets are common problems in many areas, including scientific and business domains. This need has led to substantial development of the data visualization field. In this paper, we present VMetaFlow, a graphical
Nicusor Cosmin-Toader, Fernando Trincado-Alonso, Luis Pastor, Marcos Garcia-Lorenzo   +3 more
doaj   +1 more source

Multiresolution Flow Visualization. [PDF]

, 2001
Flow visualization has been an active research field for several years and various techniques have been proposed to visualize vector fields, streamlines and textures being the most effective and popular ones. While streamlines are suitable to get rough information on the behavior of the flow, textures depict the flow properties at the pixel level ...
Jobard, Bruno, Lefer, Wilfrid
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

An adaptive LIC based geographic flow field visualization method by means of rotation distance

International Journal of Digital Earth, 2023
Geographic visualization is essential for explaining and describing spatiotemporal geographical processes in flow fields. However, due to multi-scale structures and irregular spatial distribution of vortices in complex geographic flow fields, existing ...
Yulin Ding, Daiyu Shang, Tingchen Wu, Qing Zhu, Liguo Zhang, Yongxin Guo   +5 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Bioinspired Propulsion Mechanism Using a Fin with a Dynamic Variable-Effective-Length Spring

Journal of Biomechanical Science and Engineering, 2009
Since the propulsion mechanism in fluid using an elastic fin, such as the caudal fin or the pectoral fin of fish, is effective, a number of studies have examined the use of elastic fins for propulsion in water and the development of fish robots using ...
Masataka NAKABAYASHI, Reiji KOBAYASHI, Shunichi KOBAYASHI, Hirohisa MORIKAWA   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source