Results 51 to 60 of about 596,194 (249)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Komunitas Makrozoobentos di Sungai Gua Pintu Ngalau pada Kawasan Karst di Sumatera Barat

Jurnal Biologi Universitas Andalas, 2018
Pintu Ngalau cave is flowed by river from irrigated rice fields that flows into the cave. This cave has a source of organic matter derived from bats and swallow dirts, litter that falls on enterance of the cave and the organic material carried by the ...
Husnul Mar’i, Izmiarti Izmiarti, Nofrita Nofrita   +2 more
doaj   +1 more source

Domination and effect of multi-parameters in direct chill casting based on establishment of thermo model by numerical simulation and experiment

Journal of Materials Research and Technology, 2023
In this paper, a mathematical model validated by in-situ temperature measurement data of the direct chill (DC) casting process has been established in order to study the domination and effect of multi-parameters including secondary cooling water flow ...
Jian Hou, Qichi Le, Liang Chen, Yonghui Jia, Chenglu Hu, Mohamed EI Amine Ben Seghier   +5 more
doaj   +1 more source

Data assimilation of in situ soil moisture measurements in hydrological models: first annual doctoral progress report, work plan and achievements [PDF]

, 2013
Water scarcity and the presence of water of good quality is a serious public concern since it determines the availability of water to society. Water scarcity especially in arid climates and due to extreme droughts related to climate change drive water ...
Cornelis, Wim, Joris, Ingeborg, Rezaei, Meisam, Seuntjens, Piet   +3 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Microvascular heterogeneity exploration in core and invasive zones of orthotopic rat glioblastoma via ultrasound localization microscopy

European Radiology Experimental
Background We studied the microvascular structure and function of in situ glioblastoma using ultrasound localization microscopy (ULM). Methods The in vivo study was conducted via craniotomy in six Sprague–Dawley rats.
Xing Hu, Gaobo Zhang, Yong Wang, Xiandi Zhang, Rong Xie, Xin Liu, Hong Ding   +6 more
doaj   +1 more source

Modelling Water Flow and Solute Transport for Horticultural and Environmental Management [PDF]

, 2002
During the past 10 years, the simulation model SWAP (Soil, Water, Atmosphere, Plant) was developed by the Sub-Department Water Resources of Wageningen University jointly with the Department Water and Environment of Alterra Green World Research.
Dam, J.C., van, Feddes, R.A.
core   +2 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

On the dispersion of a light chemical agent in a semi-closed environment. A theoretical study

MethodsX, 2023
Chemical events have significant public health and emergency preparedness consequences; therefore, crisis response planning is of outmost importance. The dispersion of a chemical agent in an indoor environment, near the so-called “human breathing zone ...
Evangelia Ladia
doaj   +1 more source