Results 111 to 120 of about 16,984 (307)
KONA Powder and Particle Journal, 2017 This study focuses on the periodic motion observed in the FT4 Powder Rheometer and aims to develop a new testing method to evaluate powder flowability. This new method is based on the autocorrelation analysis of the torque measurements.
Ming Li, Mikel Leturia, Khashayar Saleh
doaj +1 more source
Correlation between physical properties and flowability Indicators for fine powders [PDF]
, 2006 Approximately 80% of pharmaceutical products and the ingredients required for their manufacture are in powder form. The solid dosage form (tablets and capsules) is manufactured by either dry-blending of fine powder ingredients or combining the ...
Bodhmage, Abhaykumar Krishnarao
core
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Effect of particle size distribution on flowability of granulated lactose [PDF]
, 2019 The flowability of powders used in tableting significantly affects tablet weight and content uniformity of active pharmaceutical ingredients. Use of granulated materials instead of powdered materials can improve flowability.
Yasuda, Masatoshi +2 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Measuring powder flowability with a modified Warren Spring cohesion tester [PDF]
, 2011 The measurement of powder flowability is a major concern for most industrial processes that deal with the handling of bulk solids as raw materials, intermediates, or products. The development of devices that measure the flowability of non-aerated powders
Mohammed, S.A. +3 more
core
Parametric evaluation for powder flowability using a freeman rheometer: a discrete element method study [PDF]
, 2015 A discrete element method (DEM) using the Hertz-Mindlin and JKR models was used to model the flowability measurement on a cohesive particulate material in the Freeman FT4 powder rheometer.
Marigo, M. +4 more
core +2 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source