Results 131 to 140 of about 5,124,131 (350)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Powder flowability charaterizing technique

, 2004
Experimentally determined indices for describing the flow behaviour of powder streams in industrial storage, transport and processing operations are reviewed and discussed in terms of their range of applicability and difficulty of measurement.
Romagnoli M., BONDIOLI, Federica, ROMAGNOLI, Marcello   +2 more
core  

Filler to improve concurrent flowability and segregation performance of concrete

, 2017
Post-blending limestone (LS) filler to replace cement partially in concrete can lower the cost of production and embodied carbon. In order not to jeopardise the compressive strength, the water-to-cementitious materials (W/CM) ratio shall be kept. Because
Binhowimal, S. A. M., S. A. M. Binhowimal, Hanzic, L., Ho, J. C. M., L. Hanzic, J. C. M. Ho   +5 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Nanocomposite thermite powders with improved flowability prepared by mechanical milling

, 2018
Nanocomposite thermite powders can be used in reactive parts and components. Manufacturing these components requires tailoring powder particle size distributions, particle shapes, and powder flowability.
Nguyen, Quang, Schoenitz, Mirko, Quang Nguyen, Kyle T. Sullivan, Ci Huang, Mirko Schoenitz, Edward L. Dreizin, Huang, Ci, Sullivan, Kyle T., Dreizin, Edward L.   +9 more
core   +1 more source

Parametric evaluation for powder flowability using a freeman rheometer: a discrete element method study [PDF]

, 2015
A discrete element method (DEM) using the Hertz-Mindlin and JKR models was used to model the flowability measurement on a cohesive particulate material in the Freeman FT4 powder rheometer.
Marigo, M., Turnbull, S.A., Wilkinson, S.K., Stitt, E.H., Yan, Z.   +4 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Prediction of Ultra-High-Performance Concrete (UHPC) Properties Using Gene Expression Programming (GEP)

Buildings
In today’s digital age, innovative artificial intelligence (AI) methodologies, notably machine learning (ML) approaches, are increasingly favored for their superior accuracy in anticipating the characteristics of cementitious composites compared to ...
Yunfeng Qian, Jianyu Yang, Weijun Yang, Ali H. Alateah, Ali Alsubeai, Abdulgafor M. Alfares, Muhammad Sufian   +6 more
doaj   +1 more source