Results 221 to 230 of about 156,244 (298)

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

open access: yesAdvanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang   +10 more
wiley   +1 more source

The Transcription Factor FgSge1 Harnesses the SAGA Complex to Activate Mycotoxin Biosynthesis and Fungal Virulence

open access: yesAdvanced Science, EarlyView.
This study reveals the molecular mechanism by which the transcription factor FgSge1 regulates mycotoxin biosynthesis and virulence in Fusarium graminearum. FgSge1 binds to the TAARGTTT cis‐element, enabling self‐activation. It recruits the SAGA complex, promotes histone acetylation, and facilitates jet‐like chromatin remodeling, thereby activating ...
Yueqi Zhang   +6 more
wiley   +1 more source

Competition Between Liquid‐Liquid Crystalline Phase Separation (LLCPS) and Liquid‐Liquid Phase Separation (LLPS) in Amyloid Fibril Colloidal Systems

open access: yesAdvanced Science, EarlyView.
This study shows that amyloid fibrils form nematic condensates via liquid–liquid crystalline phase separation (LLCPS). With increasing pH, this transition shifts toward disordered condensates formed through liquid–liquid phase separation (LLPS), in which birefringence with lack of a coherent nematic field symmetry originates from enthalpic fibril ...
Milad Radiom, Raffaele Mezzenga
wiley   +1 more source

Programmable Multifunctional Bistable Structures for Energy Transfer and Dissipation

open access: yesAdvanced Science, EarlyView.
Utilizing the energy conversion characteristics of asymmetric bistable beams, this study develops a programmable multifunctional system composed of multiple bistable beams for energy transfer and dissipation. The high energy density enables the system to demonstrate potential in transient scenarios such as target delivery and shock absorption ...
Xin Na   +6 more
wiley   +1 more source

Functional group and aridity regulate impacts of climate change on plant phenology: a meta-analysis. [PDF]

open access: yesNat Commun
Sun J   +12 more
europepmc   +1 more source

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