Results 81 to 90 of about 17,014 (265)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Hierarchical Data-Flow Graphs.
, 2023 Data-Flows are crucial to detect the dependency of statements and expressions in a programming language program. In the context of Static Application Security Testing (SAST), they are heavily used in different aspects, from detecting tainted data to understanding code dependency.
Pereira, José +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
The Scientific World Journal, 2014 In this communication, we utilize some basic symmetry reductions to transform the governing nonlinear partial differential equations arising in the study of third-grade fluid flows into ordinary differential equations.
Taha Aziz, F. M. Mahomed
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
BHGNN-RT: Capturing bidirectionality and network heterogeneity in graphs.
PLoS ONEGraph neural networks (GNNs) have shown great promise for representation learning on complex graph-structured data, but existing models often fall short when applied to directed heterogeneous graphs. In this study, we proposed a novel embedding method, a
Xiyang Sun, Fumiyasu Komaki
doaj +1 more source
Refinement for Signal Flow Graphs.
, 2017 The symmetric monoidal theory of Interacting Hopf Algebras provides a sound and complete axiomatisation for linear relations over a given field. As is the case for ordinary relations, linear relations have a natural order that coincides with inclusion.
Filippo Bonchi +3 more
openaire +4 more sources
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source