Results 221 to 230 of about 99,394 (285)

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

Integrated analysis of phenotypic and SSR data reveals the genetic structure differentiation of wild <i>Rhododendron mariae</i> Hance populations in Guangdong and the driving factors for conservation planning. [PDF]

Front Plant Sci
Yan X, Guo J, Zhang Y, Ye X, Yang S, Yang Q, Zheng X.   +6 more
europepmc   +1 more source

The overlooked burden of nonattendance in hip fracture liaison models of care. [PDF]

JBMR Plus
Abad MO, Ebert M, Jin J, Padubidri A, Khan LZ.   +4 more
europepmc   +1 more source

ROS-Scavenging Bamboo-Derived Carbon Dot-Methotrexate Nanocomposite Ameliorates Rheumatoid Arthritis through Dual Therapeutic Mechanisms. [PDF]

ACS Omega
Hu XR, Wang F, Zhao BF, Xu F, Wang Y.
europepmc   +1 more source

Piezo1-mediated autophagy promotes immune-inflammatory responses in ankylosing spondylitis. [PDF]

Cell Death Dis
Zhao H, Yu X, Jiang M, Li Z, Zhao Y, Ren Y, Fang L, Wang M, Lu X, Ma Y, Wang G, Zhou Q, Zou Y, Cai G, Pan F.   +14 more
europepmc   +1 more source

Losartan alleviated synovitis in patients with metabolic osteoarthritis by down-regulating AT1R to inhibit TGF-β signaling. [PDF]

J Orthop Surg Res
Zhang H, Zhu J, He H, Li B, Wang H, Chen L, Ni Q.   +6 more
europepmc   +1 more source

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Follicular lymphoma (FL): Immunological tolerance theory in FL

Human Immunology, 2017
The ultimate cause of follicular lymphoma (FL) remains unknown. Remarkably, almost nothing is known about immunological tolerance mechanisms that might contribute to FL development. Immunological tolerance mechanisms, like other stimuli, also induce persistent changes of B cell receptors that induce genetic instability and molecular aberrations ...
Ricardo, García-Muñoz, Carlos, Panizo
openaire   +2 more sources

FL-GUARD

Proceedings of the 2017 International Conference on Cryptography, Security and Privacy, 2017
This paper proposed a new detection and prevention system against DDoS (Distributed Denial of Service) attack in SDN (software defined network) architecture, FL-GUARD (Floodlight-based guard system). Based on characteristics of SDN and centralized control, etc., FL-GUARD applies dynamic IP address binding to solve the problem of IP spoofing, and uses 3.
Jing Liu, Yingxu Lai, Shixuan Zhang
openaire   +1 more source