Results 91 to 100 of about 163,944 (309)

Improving the Effectiveness of the Annual Flu Vaccine

, 2018
Due to the rapidly mutating influenza virus, a new vaccine is usually developed for each flu season. In this policy brief, the authors discuss the current method used by the Centers for Disease Control and Prevention to develop the flu vaccine and ...
Matthews, Kirstin R.W., Bonomo, Melia E., Deem, Michael W.   +2 more
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Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Perancangan Iklan Layanan Masyarakat Tentang Virus Flu Burung Untuk Masyarakat Kota Malang

, 2009
Flu burung adalah penyakit menular hewan yang disebabkan oleh virus influenza tipe A yang menyerang unggas. Kasus flu burung dalam perkembangannya, tidak hanya menyerang unggas tetapi juga menyerang manusia.
Yuyud Setiawan; Program Studi Desain Komunikasi Visual, Jurusan Seni dan Desain, Fakultas Sastra, Universitas Negeri Malang. Pembimbing : (I) Drs. Pujiyanto, M.Sn, (II) Rudi Irawanto, S. Pd., M.Sn.
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Vers une signature spatiale de la vulnérabilité épidémiologique en France : l'exemple de la grippe

Physio-Géo, 2010
The epidemiology of infectious diseases is in the heart of the concerns of numerous authorities of Public health. This theme was reactivated by the anguishes generated by the Severe Acute Respiratory Syndrome (SARS) or more recently by the fears of a flu-
Benjamin Lysianuk, Martine Tabeaud
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Analyzing the Decision to Get Flu Shot: An Empirical Study [PDF]

Influenza vaccination has been shown to be cost effective in reducing morbidity and mortality and in decreasing work absenteeism and use of health-care resources.
Gregory Yom Din, Uri Benzion, Yoshiro Tsutsui, Shosh ShahrabaniAuthor-Name:   +3 more
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Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Who Takes Advantage of Free Flu Shots? Examining the Effects of an Expansion in Coverage

Because of the high risk of costly complications (including death) and the externalities of contagious diseases, many countries provide free flu shots to certain populations free of charge.
Mosca, I., Carman, K.G.
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