Results 101 to 110 of about 47,013 (254)

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Implications of avian flu for economic development in Kenya: [PDF]

Kenya is vulnerable to avian flu given its position along migratory bird routes and proximity to other high-risk countries. This raises concerns about the effect an outbreak could have on economic development.
Thurlow, James
core  

Factors Associated with Seasonal Influenza Vaccination Among Working-Age Adults in Poland: A Nationwide Cross-Sectional Survey

Vaccines
Background: Influenza-related absenteeism causes significant economic implications. Vaccination is the most effective intervention for preventing influenza infection and its complications.
Radosław Sierpiński, Mateusz Jankowski, Filip Raciborski   +2 more
doaj   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Red, Blue, and the Flu: Media Self-Selection and Partisan Gaps in Swine Flu Vaccinations [PDF]

This study assesses the relationship between political partisanship and attitudes and behavior with respect to the Swine Flu crisis of 2009 in general, and the U.S. mass vaccination program in particular.
Baum, Matthew A.
core  

Impact of the 2023/24 Influenza Vaccination on Patients with Inflammatory Rheumatic Disease in Germany: Insights from a Nationwide, Longitudinal, Self-Reported Study

Vaccines
Background: Patients with inflammatory rheumatic diseases (IRD) are susceptible to influenza infections and their complications. However, they may avoid vaccination for fear of exacerbating their IRD. This study evaluates the 2023/24 influenza vaccine in
Karolina Gente, Benedikt Ditz, Eike Bormann, Nadine Al-Azem, Gerd R. Burmester, Salma Charaf, Christian Fräbel, Gabriele Gilliam-Feld, Natalie Klüser, Anna Knothe, Ulf Müller-Ladner, Johannes Roth, Hendrik Schulze-Koops, Christof Specker, Mirko Steinmüller, Konstantinos Triantafyllias, Rebecca Hasseli   +16 more
doaj   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Flu pandemic : how prepared are we?

, 2017
In this podcast Professor Robert Dingwall, Director of the 'Institute of Science and Society' at the University of Nottingham, and a member of the UK government’s Department of Heath committee on the ethical aspects of pandemic influenza ...
Dingwall, Robert W.J.
core  

Immunomodulators in the treatment of acute respiratory viral infections

Якутский медицинский журнал
The survey contains an analysis of current research on the treatment of acute respiratory viral infections (ARVI) using immunomodulatory drugs available on the Russian market, and the rationality of the use of this type of medicine from the standpoint of
N. A. Lebedeva, D. S. Tomin, M. M. Vinokurov, K. G. Terekhina   +3 more
doaj   +1 more source