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A pandemia de gripe de 1918-1919: um desafio à ciência médica no princípio do século XX

Ler História, 2018
The pneumonic influenza pandemic was, on a world scale, the deadliest of the entire 20th century. Between spring 1918 and April 1919, it raged in Portugal in three successive waves, with an irregular and unusual virulence, which were marked by an intense
Helena Rebelo-de-Andrade, David Felismino   +1 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Contagious Health Risk and Precautionary Social Distancing

Frontiers in Psychology, 2021
BackgroundSince humans are social animals, social relations are incredibly important. However, in cases of contagious diseases such as the flu, social contacts also pose a health risk.
Helge Giese, Martina Gamp, F. Marijn Stok, F. Marijn Stok, Wolfgang Gaissmaier, Harald T. Schupp, Britta Renner   +6 more
doaj   +1 more source

Who can stay home with the flu? [PDF]

, 2009
As fears of a swine flu pandemic spread, President Obama and public health officials are urging Americans to stay home from work and keep their children home from school if they have flu symptoms.
Marilyn P. Watkins
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Systemic Sclerosis and Vaccinations: A Register-Based Cohort Study about Seasonal Influenza and Streptococcus pneumoniae Vaccination Rate and Uptake from Liguria Regional Center, Northwest Italy

Vaccines, 2020
Systemic sclerosis (SSc) is the connective tissue disease with the highest mortality and patients with chronic inflammatory immune-mediated diseases are at high risk of acquiring infections as they are often treated with immunosuppressive or biological ...
Giuseppe Murdaca, Giovanni Noberasco, Alberto Battaglini, Chiara Vassallo, Francesca Giusti, Monica Greco, Chiara Schiavi, Laura Sticchi, Giancarlo Icardi, Andrea Orsi   +9 more
doaj   +1 more source

Use of Artificial Intelligence to Triage Patients with Flu-Like Symptoms Using Imaging in Non-COVID-19 Hospitals during COVID-19 Pandemic: An Ongoing 8-Month Experience

Indian Journal of Radiology and Imaging, 2021
Background Evaluation of suspected coronavirus disease-2019 (COVID-19) patient is a diagnostic dilemma as it commonly presents like influenza in early stages.
Atul Kapoor, Aprajita Kapoor, Goldaa Mahajan   +2 more
doaj   +1 more source

ANALISA DESKRIPTIF TENTANG PENYULUHAN PENCEGAHAN FLU BURUNG DI KOTA PEKANBARU (descriptive analysis about the education of the prevention of avian influenza in pekanbaru city ) [PDF]

, 2008
sampai dengan Oktober 2007, kasus positif flu burung di Indonesia mencapai 108 orang, dan 87 orang dintaranya meninggal dunia. Diketahui bahwa terdapat 5 kasus positif di Provinsi Riau, dan jumlah kematian mencapai 4 orang.
ZAKIYAH, RATNA
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Rapid Tests for Viral Upper Airway Respiratory Infections in the Workplace: A Pilot Study on a Professional Football Team

Medicina
Background and Objectives: Acute infections among elite athletes are predominantly attributed to upper respiratory tract pathogens. From a practical standpoint, medical personnel responsible for the healthcare of professional football players should be ...
Dimitrios Papagiannis, George D. Vavougios, Kyriakos Yiangou, Evangelos Latzourakis, Foteini Malli, Konstantinos I. Gourgoulianis, Georgios M. Hadjigeorgiou   +6 more
doaj   +1 more source