Results 101 to 110 of about 106,245 (320)

Fluconazole and Echinocandin Resistance of Candida glabrata Correlates Better with Antifungal Drug Exposure Rather than with MSH2 Mutator Genotype in a French Cohort of Patients Harboring Low Rates of Resistance

Frontiers in Microbiology, 2016
Candida glabrata is a major pathogenic yeast in humans that is known to rapidly acquire resistance to triazole and echinocandin antifungal drugs. A mutator genotype (MSH2 polymorphism) inducing a mismatch repair defect has been recently proposed to be ...
S. Dellière, K. Healey, M. Gits-Muselli, B. Carrara, A. Barbaro, N. Guigue, Christophe Lecefel, S. Touratier, M. Desnos-Ollivier, D. Perlin, S. Bretagne, A. Alanio   +11 more
semanticscholar   +1 more source

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

A mitochondria‐targeted aggregation‐induced emission photosensitizer for eradication Candida biofilms and treating oral ulcer

Smart Molecules, EarlyView.
A mitochondria‐targeted AIE photosensitizer, LIQ‐TPA‐TZ, was developed to fight against Candida infection. It can efficiently produce reactive oxygen species to kill Candida guilliermondii and eradicate biofilms. It not only disrupted the respiratory chain and affected the metabolism and energy supply but also reduced the fungi adhesion and filament ...
Kun‐Mei Liu, Yun Wang, Feng‐Wei Xia, Shun Feng, Xiao‐Qi Yu, Ming‐Yu Wu   +5 more
wiley   +1 more source

In vitro activities of antifungal agents alone and in combination against fluconazole-susceptible and -resistant strains of Candida dubliniensis

Brazilian Journal of Infectious Diseases, 2012
In the present study we used two groups of Candida dubliniensis strains: one containing fluconazole-susceptible clinical isolates and another containing fluconazole-resistant laboratory derivative from the former to examine the changes on susceptibility ...
Liliane Alves Scheid, Débora Alves Nunes Mario, Thaís Felli Kubiça, Janio Morais Santurio, Sydney Hartz Alves   +4 more
doaj  

Fluconazole and Ibuprofen Combination: A Potential Treatment for Mucosal Candidiasis

Medical Laboratory Journal, 2020
Background and objectives: The incidence of drug-resistant candidiasis has increased dramatically. This study aimed to evaluate antifungal effects of fluconazole alone and in combination with ibuprofen on isolates from patients with mucosal candidiasis.  
Tahere Shamoushaki, Leila Fozouni
doaj  

Exposure to Systemic Antimicrobials During Pregnancy and Risk of Miscarriage: A Population‐Based Registry Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To estimate miscarriage risk following gestational antimicrobial exposure while addressing biases that have affected previous studies. Design Population‐based cohort study. Setting Linkage of four nationwide registries: Medical Birth Registry of Norway (MBRN), Norwegian Prescribed Drug Registry (NorPD), Norwegian Patient Registry ...
Thomas Boissiere‐O'Neill, Marleen M. H. J. van Gelder, Hilde M. Engjom, Hedvig M. E. Nordeng   +3 more
wiley   +1 more source

Voriconazole treatment of Candida tropicalis meningitis: persistence of (1,3)-b-D-glucan in the cerebrospinal fluid is a marker of clinical and microbiological failure [PDF]

, 2016
Introduction: Infections are still the most common complications of cerebral shunt procedures. Even though fungal etiologies are considered to be rare, they are associated with significant morbidity and mortality.
Brunetti, Grazia, Ceccarelli, Giancarlo, Fallani, Stefania, Ghezzi, Maria Cristina, Marsiglia, Carolina, Novelli, Andrea, Raponi, Giammarco, Venditti, Mario   +7 more
core   +2 more sources

Fluconazole levels in serum and cerebrospinal fluid according to daily dosage in patients with cryptococcosis and other fungal infections

Brazilian Journal of Infectious Diseases, 2018
Fluconazole is extensively used for the treatment of candidiasis and cryptococcosis. Among other factors, successful treatment is related to appropriate fluconazole levels in blood and cerebrospinal fluid.
Letícia Aparecida Schiave, Erika Nascimento, Fernando Crivelenti Vilar, Tissiana Marques de Haes, Osvaldo Massaiti Takayanagui, Cristiane Masetto de Gaitani, Roberto Martinez   +6 more
doaj  

Candida auris, what do paediatricians need to know? [PDF]

, 2018
AW is supported by the Wellcome Trust Strategic Award (grant 097377) and the MRC Centre for Medical Mycology (grant MR/N006364/1) at the University of Aberdeen.Peer reviewedPublisher ...
Warris, Adilia
core   +1 more source

Cell wall composition and biofilm formation of azoles-susceptible and -resistant Candida glabrata strains [PDF]

, 2011
In the present study, three strains of Candida glabrata have been investigated to shed light on the mechanisms involved in azole resistance during adherence and biofilm formation.
Vitali, Alberto, Vavala, Elisabetta, Marzano, Valeria, Leone, Claudia, Castagnola, Massimo, Iavarone, Federica, Angiolella, Letizia   +6 more
core   +5 more sources