Results 121 to 130 of about 61,779 (245)

Dose-dependent inhibition of cyclosporine metabolism in mice by fluconazole

, 1990
Fluconazole, a potent bis-triazole antimycotic drug, has been demonstrated to inhibit antipyrine metabolism, a cytochrome P-450 dependent process, in vivo in mice.
Ignazio La Delfa, Terrence F. Blaschke, Yifan Xia   +2 more
core   +1 more source

Coumarin‐Based Antifungal Leads: Design, Synthesis, Mechanistic Insights, and Synergistic Activity

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
A series of novel coumarin derivatives are designed and synthesized as antifungal leads. The optimized compound IVd displays potent activity against plant pathogens, potential multitarget antifungal effects, and synergistic interactions with commercial fungicides, providing a promising strategy for resistance management.
Xiangna Chang, Qiang Du, Xiaoying Ma, Jundi Zhang   +3 more
wiley   +1 more source

Treatment of experimental cryptococcal meningitis with fluconazole: impact of dose and addition of flucytosine on mycologic and pathophysiologic outcome

, 1996
Fluconazole is effective in the therapy of cryptococcal meningitis in patients with AIDS. The optimal dosage of fluconazole and the impact of combination with flucytosine are not known.
Kartalija, M, Kaye, K, Täuber, MG, Tureen, JH, Liu, Q, Elliott, BR, Sande, MA, J. H. Tureen, M. A. Sande, Q. Liu, B. R. Elliott, K. Kaye, M. Kartalija, M. G. Tauber, Täuber, Martin G.   +14 more
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Nicotinamide and Sodium Butyrate Double the Pool of Treatment‐Exclusive Metabolites in the Endophytic Fungus Curvularia sp. G6‐32

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Epigenetic modulators nicotinamide and sodium butyrate reshape the chemical landscape of the endophytic fungus Curvularia sp. G6‐32. Combining the OSMAC strategy with UHPLC‐MS/MS metabolomics and molecular networking reveals a more than twofold rise in treatment‐exclusive metabolites, including diketopiperazines and potentially bioactive natural ...
Guilherme Edison Almeida Pega, Laís Stella Perassolli Nicchio, Andressa Domingos Polli, Francielli Alana Pereira Valeze, Évelin Lemos de Oliveira, Eduardo Cesar Meurer, Débora Cristina Baldoqui, João Lúcio Azevedo, Julio Cesar Polonio   +8 more
wiley   +1 more source

Lipase Gene Expression of Resistant and Sensitive Candida Albicans to Fluconazole Isolated from Patients Suffering from Oral Candidiasis and Vaginal Candidiasis

Medical Laboratory Journal, 2015
Background and Objective: With the development of drug resistance in strains of fungi, there is a considerable resistance of Candida albicans strains to fluconazole. Molecular studies are developing to determine the relationship of such a drug resistance
Nasrollahi Omran, A, Nazemi, A, Kihanian, SH, Aryana , N   +3 more
doaj  

Lengthening of QT Interval Caused by Fluconazole in a Newborn

, 2012
Fluconazole is a broadly used drug, especially in critically ill newborns hospitalized in neonatal intensive care units. The drug is safe and effective in both prophylaxis and treatment of fungal infections in newborns.
Aydın, Mustafa, Dilli, Dilek, Zenciroğlu, Ayşegül, Uzunalıç, Nuran, Okumuş, Nurullah, Aydın, Banu   +5 more
core   +1 more source

UHPLC/MS‐MS Profiling, Antioxidant and Antimicrobial Properties of Atriplex halimus L. and Marrubium deserti De Noé Extracts: In Vitro and In Silico

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
This study investigates the phytochemical profile and biological potential of Atriplex halimus L. and Marrubium deserti De Noé extracts. Polyphenolic constituents are identified using UHPLC‐MS/MS analysis, complemented by TPC and TFC evaluations. Antioxidant activities are determined via DPPH, ABTS, and FRAP assays, while antimicrobial efficacy is ...
Nacira Siad, Chahrazed Hamia, Amar Djeridane, Mohamed Benalia, Reguia Mahfoudi, Hicham Bouakkaz, Mustafa Abdullah Yilmaz, Oguz Cakir, Abbas Tarhan, Mohamed Yousfi   +9 more
wiley   +1 more source

Retinal toxicity of intravitreally injected plain and liposome formulation of fluconazole in rabbit eye

Indian Journal of Ophthalmology, 2006
Purpose: Candidal endophthalmitis is a sight-threatening ocular infection that most frequently occurs as a complication of candidemia. Fluconazole has been effective against Candida albicans in various animal models.
Velpandian Thirumurthy, Narayanan Kanniapan, Nag Tapas, Ravi Alok, Gupta Suresh   +4 more
doaj  

Integrative Assessment of Teucrium Extracts: Phytochemical Profile, Nutritional‐Mineral Composition, Biological Activities, and Toxicological Assessment In Vitro and In Vivo

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Both Teucrium montanum L. and Teucrium capitatum L. underwent thorough chemical characterization and bioactivity assessment. The extracts showed strong cytotoxic, antimicrobial, and antioxidant activities, while toxicological investigations verified their low toxicity, emphasizing their safety.
Kenan Preljević, Ivana Pašić, Milorad Vlaović, Svetlana Perović, Slađana Krivokapić, Tatjana Stanojković, Ana Todorović, Katarina Bobić, Dejan Jančić, Milka Jadranin, Gorica Vuković, Andrej Perović, Biljana Damjanović‐Vratnica, Ivana Z. Matić   +13 more
wiley   +1 more source

Dose Optimization of Fluconazole After Initial Treatment Failure in Pulmonary Cryptococcosis in an Obese Patient with Type 2 Diabetes and Cirrhosis: A Case Report [PDF]

Yang Yang,1 Jin Shang,2 Shuyun Xu,2 Zhen Wang1 1Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine ...
Yang Y, Shang J, Xu S, Wang Z
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