Results 121 to 130 of about 48,304 (212)

Synthesis and Biological Evaluation of Novel 2‐(Piperidin‐4‐yl)‐1,2,3,4‐tetrahydroisoquinoline and 2‐(Piperidin‐4‐yl)decahydroisoquinoline Antimycotics

open access: yesArchiv der Pharmazie, Volume 358, Issue 10, October 2025.
A series of 13 hybrid molecules of both lead structures were prepared using reductive amination as key reaction step. The antimycotic potency of the resulting compounds was evaluated against yeast and mold species. Two compounds showed remarkable potency against several yeasts, and even against Candida krusei.
Marie‐Christin Hain   +4 more
wiley   +1 more source

A Rare Case of Blastomycosis in a Psoriasis Patient Treated With Ustekinumab (Stelara)

open access: yesClinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Psoriasis is a chronic inflammatory skin condition mediated by T‐helper 1 (Th1) and T‐helper 17 (Th17) cytokines, including interleukin (IL)‐12, IL‐23, IL‐17, and tumor necrosis factor alpha (TNF‐α). Ustekinumab, a human monoclonal antibody against the p40 subunit of IL‐12/23, has revolutionized treatment of moderate to severe psoriasis but ...
Fatima Ghaffar   +6 more
wiley   +1 more source

Complete Resolution of Cutaneous Leishmaniasis With a Novel Topical Combination Therapy: A Case Series

open access: yesClinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Cutaneous leishmaniasis (CL) remains a therapeutic challenge in endemic regions, with 600,000–1 million new cases annually facing limited treatment options. We present a case series evaluating an innovative topical combination therapy for acute‐phase CL in Shiraz, Iran.
Hoda Haghshenas   +3 more
wiley   +1 more source

Comprehensive Management of HIV With Multiple Opportunistic Infections: A Case Report

open access: yesClinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Effective management of human immunodeficiency virus patients with multiple opportunistic infections requires a multidisciplinary approach, timely initiation of antiretroviral therapy, and careful adjustment for drug–drug interactions. Coordinated care and vigilant monitoring significantly improve survival and highlight the importance of ...
Mohammad Javad Boozhmehrani   +10 more
wiley   +1 more source

Elucidation of the mechanisms of fluconazole resistance and repurposing treatment options against urinary Candida spp. isolated from hospitalized patients in Alexandria, Egypt

open access: yesBMC Microbiology
Background The incidence of fungal urinary tract infections (UTIs) has dramatically increased in the past decades, with Candida arising as the predominant etiological agent.
Hend Zeitoun   +4 more
doaj   +1 more source

SGLT2 Inhibitors and Complicated Urinary Tract Infections: A Rare Case of Emphysematous Pyelonephritis and Subsequent Recurrence Associated With Dapagliflozin Use

open access: yesClinical Case Reports, Volume 13, Issue 10, October 2025.
CT scan of abdomen and pelvis demonstrating left renal pelvis calculus and parenychemal gas involving the posterior interpolar region, consistent with emphysematous pyelonephritis. ABSTRACT Clinicians should exercise caution when prescribing dapagliflozin, a sodium‐glucose co‐transporter‐2 (SGLT2) inhibitor, as it may increase the risk of severe and ...
Harveen Kaur   +2 more
wiley   +1 more source

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