Results 121 to 130 of about 106,245 (320)

Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study.

Clinical Infectious Diseases, 2006
BACKGROUND Inadequate antimicrobial treatment is an independent determinant of hospital mortality, and fungal bloodstream infections are among the types of infection with the highest rates of inappropriate initial treatment.
K. Garey, M. Rege, M. Pai, Dana E Mingo, K. Suda, R. Turpin, D. Bearden   +6 more
semanticscholar   +1 more source

A review of the safety of sodium‐glucose co‐transporter‐2 inhibitors

Diabetes, Obesity and Metabolism, EarlyView.
Abstract The development of sodium‐glucose co‐transporter‐2 (SGLT2) inhibitors represents a major turning point in the effort to preserve kidney function and prevent cardiovascular events and heart failure hospitalisations in those at high risk. These agents have now transcended their original glucose‐lowering indication and provide a range of clinical
Daniel Vincent O'Hara, Meg J. Jardine
wiley   +1 more source

An investigation into the pathogenesis of vulvo-vaginal candidosis [PDF]

, 2001
OBJECTIVE: To monitor yeasts isolated from women during and between episodes of recurrent vulvo-vaginal candidosis (VVC) to determine whether vaginal relapse or re-infection occurred. METHODS:Women presenting at the genitourinary medicine clinic with
Ashbee, H.R., Barton, R.C., El-Din, S.S., Evans, E.G.V., Reynolds, M.T.   +4 more
core   +2 more sources

Single‐Dose, Intravenous, and Oral Pharmacokinetics of Isavuconazole in Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Isavuconazole, a triazole antifungal used in humans for invasive fungal infections, may be effective for treating canine fungal infections, although data on its use in dogs is limited. This study aimed to determine the pharmacokinetics and safety of a single dose of isavuconazole in dogs, administered both intravenously and orally. Six healthy
Yishan Kuo, Zhong Li, Lauren E. Forsythe, Jennifer M. Reinhart   +3 more
wiley   +1 more source

Correlation between ERG11 Gene Mutations and Fluconazole Resistance in Candida albicans Strains Isolated from Rasht in Years 2015-2016 [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2017
Background: Candida albicans as an opportunistic fungal pathogen in human causes candidiasis. The widespread use of azoles has led to the increase of azole resistance in Candida albicans isolates.
Saeedeh Balabandi, Zeinab Khazaei-Koohpar, Najmeh Ranji   +2 more
doaj  

In Vitro Activities of Novel Azole Compounds ATTAF-1 and ATTAF-2 against Fluconazole-Susceptible and -Resistant Isolates of Candida Species

Antimicrobial Agents and Chemotherapy, 2016
The in vitro activities of two novel azole compounds (aryl-1,2,4-triazol-3-ylthio analogues of fluconazole [ATTAFs]) and five comparator antifungal agents against 52 clinical Candida isolates from 5 different species were determined.
H. Fakhim, S. Emami, A. Vaezi, Seyedeh Mahdieh Hashemi, Leila Faeli, K. Diba, E. Dannaoui, H. Badali   +7 more
semanticscholar   +1 more source

Early and Accurate Pathogen Identification Based on mNGS: Key to Timely Therapy for Mycoplasma Prosthetic Joint Infection

Orthopaedic Surgery, EarlyView.
Prior invasive urinary catheterization represents a significant risk factor for Mycoplasma PJI. The synergistic use of mNGS, optimized culture methods, and 16S rRNA PCR enables early detection of Mycoplasma. The multimodal diagnostic approach significantly enhances Mycoplasma identification accuracy, minimizes diagnostic oversights, and provides ...
Zhenyuan Lin, Yang Chen, Zhenggui Yu, Zeyu Zhang, Yiming Lin, Wenming Zhang, Wenbo Li, Yufeng Guo, Xinyu Fang   +8 more
wiley   +1 more source

Increasing trend of fluconazole-non-susceptible Cryptococcus neoformans in patients with invasive cryptococcosis: a 12-year longitudinal study

BMC Infectious Diseases, 2015
BackgroundThis study aimed to investigate the rate of fluconazole-non-susceptible Cryptococcus neoformans in Southern Taiwan for the period 2001–2012 and analyze the risk factors for acquiring it among patients with invasive cryptococcosis.MethodsAll ...
Yi-Chun Chen, Tzu-Yao Chang, Jien-Wei Liu, Fang-Ju Chen, C. Chien, Chen-Hsiang Lee, Cheng-Hsien Lu   +6 more
semanticscholar   +1 more source

Presumed Trichophyton indotineae Infection in Children: A Call for Heightened Clinical Awareness

Pediatric Dermatology, EarlyView.
ABSTRACT Trichophyton indotineae is a fungus that is often antifungal‐resistant and presents with exuberant infection. It has been increasingly reported across the world, posing significant diagnostic challenges. We describe a case of a toddler with a history of travel to Bangladesh, presenting with persistent annular scaling plaques of dermatophytosis
Sriram Palepu, James R. Treat
wiley   +1 more source

Biofilm-forming capability of highly virulent, multidrug-resistant Candida auris [PDF]

, 2017
The emerging multidrug-resistant yeast pathogen Candida auris has attracted considerable attention as a source of healthcare–associated infections. We report that this highly virulent yeast has the capacity to form antifungal resistant biofilms sensitive
Borman, Andrew, Johnson, Elizabeth M., Kean, Ryan, Ramage, Gordon, Rautemaa-Richardson, Riina, Richardson, Malcolm D., Sherry, Leighann   +6 more
core   +3 more sources