Results 121 to 130 of about 82,470 (284)

Use of Real‐World Claims Data to Assess the Prevalence of Concomitant Medications to Inform Drug–Drug Interaction Risk in Target Patient Populations

open access: yesClinical Pharmacology &Therapeutics, Volume 118, Issue 1, Page 146-155, July 2025.
A common issue in clinical drug development involves drug–drug interactions (DDI) that may lead to altered drug exposure and subsequent altered safety and efficacy of an investigational drug or concomitant medications (conmeds) in the target patient population.
Alice S. Tang   +6 more
wiley   +1 more source

Synergistic Anti-Candida Activity of Bengazole A in the Presence of Bengamide A †. [PDF]

open access: yes, 2019
Bengazoles A⁻G from the marine sponge Jaspis sp. exhibit potent in vitro antifungal activity against Candida spp. and other pathogenic fungi. The mechanism of action (MOA) of bengazole A was explored in Candida albicans under both liquid culture and ...
Cheng, Tina   +3 more
core  

Tomato Disease Combat and Yield Optimization Using Selenium Nanoparticles: A Sustainable Nano‐Agriculture Approach

open access: yesFood Science &Nutrition, Volume 13, Issue 7, July 2025.
This study aimed to explore the effectiveness of Selenium nanoparticles (SeNPs) in combating the devastating pathogens of tomato crop. The study also optimized the dosage of SeNPs, for potential antimicrobial and pesticidal efficacy. ABSTRACT Tomatoes are a crucial component of the global food system but are susceptible to pests and diseases, such as ...
Zainab Maqbool   +4 more
wiley   +1 more source

Shedding Light on the Phytochemical and Biological Fingerprints of Fibigia clypeata (L.) Medik Essential Oil as a Pharmacotherapeutic Agent

open access: yesFood Science &Nutrition, Volume 13, Issue 7, July 2025.
This study aims to analyze the phytochemical composition and in silico and in vitro biological activity of Fibigia clypeata (L.) Medik essential oil is a natural pharmaceutical source for the first time in the literature. GC–MS Analysis showed that dimethyl disulfide and dimethyl trisulfide were the main compounds of the plant essential oil.
Tuba Unver   +6 more
wiley   +1 more source

Cytotoxicity of fluconazole on canine dental pulp-derived stem cells

open access: yesJournal of Oral Biology and Craniofacial Research, 2020
Objective: In order to use fluconazole as an antifungal in cell cultures, we evaluated its possible cytotoxic effects and its influence on the proliferation and viability of canine dental pulp-derived stem cells (cDPSCs).
Paulo Henrique Utumi   +8 more
doaj  

A Controlled Trial of Fluconazole to Prevent Fungal Infections in Patients Undergoing Bone Marrow Transplantation [PDF]

open access: bronze, 1992
Jesse L. Goodman   +20 more
openalex   +1 more source

Vaginal azoles versus oral fluconazole in treatment of recurrent vulvovaginal candidiasis [PDF]

open access: yes
Background: Vulvovaginal candidiasis (VVC) is a fungal infection of the vagina and vulva. It is usually caused by Candida albicans, however, occasionally other candida species are responsible. The optimal treatment of VVC has not yet been defined.
تلو, مهشید   +3 more
core  

Aggressive Head and Neck Squamous Cell Carcinoma in the Setting of GATA2 Deficiency

open access: yesHead &Neck, Volume 47, Issue 7, Page E82-E86, July 2025.
ABSTRACT Background GATA2 deficiency is a rare genetic disorder associated with hematologic, infectious, and neoplastic complications. We report a case of a patient with GATA2 deficiency who developed aggressive squamous cell carcinoma (SCC) of the head and neck, an atypical manifestation of this condition.
Brejjette Aljabi   +3 more
wiley   +1 more source

Biological and Computational Study of the Dual Antimicrobial and Anticancer Potential of 3,4‐Dihydropyrimidin‐2(1H)‐ones and Thiones

open access: yesChemistrySelect, Volume 10, Issue 26, July 11, 2025.
Sixteen 3,4‐dihydropyrimidin‐2(1H)‐ones and ‐thiones were synthesized and evaluated for antimicrobial activity against both resistant and nonresistant bacterial strains, as well as for fungal species. Two compounds 16 and 25 inhibiting biofilm formation by 70.22%, and 54.67%, respectively. 20 and 24 were the most potent as antibacterial and antifungal.
Natalia Ciobanu   +13 more
wiley   +1 more source

Lipase Gene Expression of Resistant and Sensitive Candida Albicans to Fluconazole Isolated from Patients Suffering from Oral Candidiasis and Vaginal Candidiasis

open access: yesMedical Laboratory Journal, 2015
Background and Objective: With the development of drug resistance in strains of fungi, there is a considerable resistance of Candida albicans strains to fluconazole. Molecular studies are developing to determine the relationship of such a drug resistance
Nasrollahi Omran, A   +3 more
doaj  

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