Results 81 to 90 of about 62,274 (300)

Credibility Methods for Individual Life Insurance

Risks, 2018
Credibility theory is used widely in group health and casualty insurance. However, it is generally not used in individual life and annuity business. With the introduction of principle-based reserving (PBR), which relies more heavily on company-specific ...
Yikai (Maxwell) Gong, Zhuangdi Li, Maria Milazzo, Kristen Moore, Matthew Provencher   +4 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Nonlinear self-induced vibration and operability envelope analysis of production strings in marine natural gas development

International Journal of Naval Architecture and Ocean Engineering, 2019
Marine production strings are continuously affected by unstable internal fluid during operation. In this paper, the structural governing equation for marine production string self-induced vibration is constructed.
Kang Liu, Guoming Chen, Gaogeng Zhu, Jingyu Zhu   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

202 Helvetica Physica Acta, Vol. 51 (1978), Birkhliuser Verlag, Basel Stochastic processes II:

, 2014
. Linear and nonlinear response theory are developed for stationary Markov systems describing systems in equilibrium and nonequilibrium. Generalized fluctuation theorems are derived which relate the response function to a correlation of nonlinear ...
Response Theory, Fluctuation Theorems
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Variational Structures Beyond Gradient Flows: a Macroscopic Fluctuation-Theory Perspective

Macroscopic equations arising out of stochastic particle systems in detailed balance (called dissipative systems or gradient flows) have a natural variational structure, which can be derived from the large-deviation rate functional for the density of the
Renger, D. R. Michiel, Sharma, Upanshu, Patterson, Robert I. A.   +2 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Fluctuation properties of interfaces and membranes bounded by self-affine surfaces

, 1997
In this work we study fluctuation properties of fluid interfaces/membranes bounded by a rough self-affine surface. We find that the fractal character of the substrate affects the interface/membrane roughness significantly for healing lengths ...
Backx, G. (author), Palasantzas, G., Backx, G., Dep Natuurkunde, Universiteit Utrecht, Palasantzas, G. (author), Condensed Matter Theory, Statistical and Computational Physics   +6 more
core   +1 more source