Results 31 to 40 of about 8,610,294 (201)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Advanced Instrumentation for Measuring Fluid-Structure Coupling Phenomena in the Guide Vanes Cascade of a Pump-Turbine Scale Model [PDF]

, 2010
In the present study, the fluid-structure coupling is investigated in the guide vanes of a pump-turbine scale model placed in one of the test rigs of the Laboratory for Hydraulic Machines (EPFL) in Lausanne.
Avellan, François, Roth, Steven, Hasmatuchi, Vlad, Francisco Botero, Vlad Hasmatuchi, Botero, Francisco, Steven Roth, Mohamed Farhat, Farhat, Mohamed, Francois Avellan   +9 more
core   +2 more sources

Vibroacoustic Modeling of Mechanically Coupled Structures: Artificial Spring Technique Applied to Light and Heavy Mediums

Shock and Vibration, 1996
This article deals with the modeling of vibrating structures immersed in both light and heavy fluids, and possible applications to noise control problems and industrial vessels containing fluids. A theoretical approach, using artificial spring systems to
L. Cheng
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Challenges of fully-coupled high-fidelity ditching simulations

MATEC Web of Conferences, 2018
An important element of the process of aircraft certification is the demonstration of the crashworthiness of the structure in the event of an emergency landing on water, also referred to as ditching.
Müller Maximilian, Woidt Malte, Haupt Matthias, Horst Peter   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Vibration characteristics of composite plates considering fluid-structure coupling

Advances in Mechanical Engineering
In order to investigate the influence of fluid-structure coupling on the dynamic characteristics of the amphibious aircraft, the free vibration characteristics of composite plates in contact with a bounded fluid are studied based on the combination of ...
Chen Wang, Qiang Liu
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Numerical Simulation of a Submerged Floating Tunnel: Validation and Analysis

Applied Sciences
The dynamic response analysis of submerged floating tunnels (SFTs) under seismic action is a complex two-way fluid–structure coupling problem that requires expertise in structural dynamics, fluid mechanics, and advanced computational methods. The coupled
Hao Li, Xiaohui Cheng, Hua Pan
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source