Results 51 to 60 of about 71,615 (220)
机车电传动, 2013 In order to study safety of train passing by each other with consideration of fluid-solid coupling friendship and avoid the large damage to structure and running safety from the interaction of train and air, a new numerical analysis method of fluid-solid
CUI Tao, ZHANG Wei-hua, WANG Yan
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Modal Analysis of Vibration Reed of Hydrodynamic Sounder
Shiyou jixie, 2020 Hydrodynamic sounders are widely used in industrial production. They are suitable for dealing with organic polluted water and plug removal in the oil production process.
Shi Yinghua +6 more
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Analysis on the fluid-structure interaction vibration characteristics of the elastic propeller
Zhongguo Jianchuan Yanjiu, 2020 [Objectives] In the flow field, vibration response characteristics of the elastic propeller are influenced by the interaction of the fluid and structure.[Methods] Based on the CFD/FEM fluid-structure interaction method,ANSYS-CFX modules on the Workbench ...
TAN Yuhang, PENG Weicai
doaj +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Shock and Vibration, 2019 A 1.5 MW horizontal-axis wind turbine blade and fluid field model are established to study the difference in the unsteady flow field and structural vibration of the wind turbine blade under one- and two-way fluid-structure interactions.
Rui Zhu, Da-duo Chen, Shi-wei Wu
doaj +1 more source