Results 71 to 80 of about 195,182 (264)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Partitioned coupling of fluid-structure interaction for the simulation of floating wind turbines

, 2019
Fluid-structure interaction problems appear in many different fields of application. An interesting and highly topical field is offshore renewable energy.
König, Marcel, Lund, Jorrid, Radtke, Lars, Wiegard, Bjarne, Düster, Alexander   +4 more
core   +1 more source

Vibration analysis of hydropower house based on fluid-structure coupling numerical method

Water Science and Engineering, 2010
By using the shear stress transport (SST) model to predict the effect of random flow motion in a fluid zone, and using the Newmark method to solve the oscillation equations in a solid zone, a coupling model of the powerhouse and its tube water was ...
Shu-he Wei, Liao-jun Zhang
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Fluid Structure Interaction (FSI) Simulation of the human eye under the air puff tonometry using Computational Fluid Dynamics (CFD) [PDF]

, 2018
The air puss test is a non-contact method used in different areas to investigate the material behaviour or the biomechanical properties of biological tissues such as skin, cornea, and soft tissue tumours and also to study fruit rmness or meat tenderness.
Maklad, O, Theofilis, V., Theofilis, V, Elsheikh, A, Maklad, Osama, Elsheikh, A.   +5 more
core  

Numeric Analysis Method of Fluid-Solid Coupling Vibration in Train Passing by Each Other at High Speed

机车电传动, 2013
In order to study safety of train passing by each other with consideration of fluid-solid coupling friendship and avoid the large damage to structure and running safety from the interaction of train and air, a new numerical analysis method of fluid-solid
CUI Tao, ZHANG Wei-hua, WANG Yan
doaj  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Development of High-Performance Soft Robotic Fish by Numerical Coupling Analysis

Applied Bionics and Biomechanics, 2018
To design a soft robotic fish with high performance by a biomimetic method, we are developing a soft robotic fish using piezoelectric fiber composite (PFC) as a flexible actuator.
Wenjing Zhao, Aiguo Ming, Makoto Shimojo
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source