Results 71 to 80 of about 8,610,294 (201)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
An experimental analysis of fluid structure interaction on a flexible hydrofoil in various flow regimes including cavitating flow [PDF]
, 2012 The authors gratefully acknowledge the technical staff of IRENav for its contribution to the experimental set up.The structural response of a rectangular cantilevered flexible hydrofoil submitted to various flow regimes is analyzed through an original ...
SIGRIST, Jean-François +2 more
core +1 more source
Shock and Vibration, 2019 A 1.5 MW horizontal-axis wind turbine blade and fluid field model are established to study the difference in the unsteady flow field and structural vibration of the wind turbine blade under one- and two-way fluid-structure interactions.
Rui Zhu, Da-duo Chen, Shi-wei Wu
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Acceleration of fluid-structure interaction procedures by anticipatory coupling [PDF]
, 2017 Simulating the hydrodynamics of floating structures using a two-way partitioned coupling poses a major challenge when the coupling between the fluid and the structure is strong.
Seubers, J. H., Veldman, A. E.P.
core +4 more sources
High-Order Vibroacoustic Modal Analysis Framework for Fluid-Structure Coupling
AerospaceThis work develops and validates a high-order, three-dimensional Carrera Unified Formulation (CUF) framework for coupled structural–acoustic eigenanalysis, aiming at accurate low-frequency modal characterization of interior cavity-structure systems with ...
Dario Magliacano
doaj +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source