Results 71 to 80 of about 389,563 (238)

Influence of Hydrodynamic Interactions on Mechanical Unfolding of Proteins

, 2007
We incorporate hydrodynamic interactions in a structure-based model of ubiquitin and demonstrate that the hydrodynamic coupling may reduce the peak force when stretching the protein at constant speed, especially at larger speeds.
Abe H, Anselle G C, Cichocki B, Cieplak M, Cieplak M, Dhont J K G, Dickinson E, Durlofsky L, Ermak D L, Felderhof B U, Hoang T X, Irbäck A, Kim S, Ladd A J C, Larson R G, Lemak A, Lorentz H A, Lu H, Makarov D, Marek Cieplak, Mazo R M, Mazur P, Nägele G, P Szymczak, Phung T N, Rotne J, Rzehak R, Schlierf M, Sułkowska J I, Szymczak P, Takada S, Tanaka H, Tanaka H, Tsai J, Veitshans T, Wojtaszczyk P, Yamakawa H   +36 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Coupling techniques for partitioned fluid-structure interaction simulations with black-box solvers [PDF]

, 2009
In partitioned simulations of fluid‐structure interaction, the flow and the displacement of the structure are calculated separately and coupling iterations between the flow solver and the structural solver are required to calculate the solution of the ...
Annerel, Sebastiaan, Degroote, Joris, Haelterman, Robby, Vierendeels, Jan   +3 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Hybrid finite difference/finite element immersed boundary method [PDF]

, 2017
The immersed boundary method is an approach to fluid-structure interaction that uses a Lagrangian description of the structural deformations, stresses, and forces along with an Eulerian description of the momentum, viscosity, and incompressibility of ...
Griffith, Boyce E., Luo, Xiaoyu
core   +3 more sources

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Modal Analysis of Vibration Reed of Hydrodynamic Sounder

Shiyou jixie, 2020
Hydrodynamic sounders are widely used in industrial production. They are suitable for dealing with organic polluted water and plug removal in the oil production process.
Shi Yinghua, Zhu Anchang, Chen Shengming, Huang Tiancheng, Li Meiqiu, Ning Linfei, Shen Jingjie   +6 more
doaj  

Flow curves of colloidal dispersions close to the glass transition: Asymptotic scaling laws in a schematic model of mode coupling theory

, 2008
The flow curves, viz. the curves of stationary stress under steady shearing, are obtained close to the glass transition in dense colloidal dispersions using asymptotic expansions in a schematic model of mode coupling theory.
C. Beck, D. Hajnal, F. Varnik, F. Varnik, G. Petekidis, J. Bender, J.J. Crassous, J.J. Crassous, J.M. Brader, M. Fuchs, M. Fuchs, M. Fuchs, M. Fuchs, M. Fuchs, R. Ganapathy, W. Götze, W. Götze, W. Götze, W. Megen, W. Megen, W. Megen   +20 more
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source