Results 61 to 70 of about 535,753 (327)

Analysis of Aerodynamic Noise Characteristics of High-Speed Train Pantograph with Different Installation Bases

Applied Sciences, 2019
The high-speed-train pantograph is a complex structure that consists of different rod-shaped and rectangular surfaces. Flow phenomena around the pantograph are complicated and can cause a large proportion of aerodynamic noise, which is one of the main ...
Yongfang Yao, Zhenxu Sun, Guowei Yang, Wen Liu, Prasert Prapamonthon   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Research on aerodynamic optimization of high-speed train’s slipstream

Engineering Applications of Computational Fluid Mechanics, 2020
Slipstream severely affects the safety of trackside workers and equipment. With use of profile superimposition method and vehicle modeling method, parametrization of the whole train is carried out. Then, a slipstream optimization study has been performed,
Zhenxu Sun, Shuanbao Yao, Guowei Yang
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Analysis of the Transonic Buffet Characteristics of Stationary and Pitching OAT15A Airfoil

Applied Sciences
Transonic buffet flow is a classical complex and unstable flow that has a negative effect on aircraft fly safety. Therefore, it is crucial to study the unsteady characteristics of buffet flow. The numerical analysis method is very useful in achieving the
Xueyuan Nie, Guannan Zheng, Lianyi Wei, Chengde Huang, Guowei Yang, Zhanling Ji   +5 more
doaj   +1 more source

Robin Based Semi-Implicit Coupling in Fluid-Structure Interaction: Stability Analysis and Numerics [PDF]

, 2009
International audienceIn this report, we propose a semi-implicit coupling scheme for the numerical simulation of fluid-structure interaction systems involving a viscous incompressible fluid. The scheme is stable irrespectively of the so-called added-mass
Astorino, Matteo, Chouly, Franz, Fernández, Miguel Angel   +2 more
core   +4 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Data-Driven Adaptive Control of Transonic Buffet via Localized Morphing Skin

Aerospace
Transonic shock buffet, characterized by large-amplitude self-sustained shock oscillations arising from shock wave/boundary layer interactions, poses significant challenges to aircraft handling quality and structural integrity.
Yuchen Zhang, Lianyi Wei, Yiqiu Jin, Han Tang, Guannan Zheng, Guowei Yang   +5 more
doaj   +1 more source

Effects of finite strains in fully coupled 3D geomechanical simulations [PDF]

, 2019
Numerical modeling of geomechanical phenomena and geo-engineering problems often involves complex issues related to several variables and corresponding coupling effects.
De Marchi, Nico, Salomoni, Valentina, Spiezia, Nicol\uf2   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source