Results 61 to 70 of about 3,742,515 (329)

Analysis of the Transonic Buffet Characteristics of Stationary and Pitching OAT15A Airfoil

Applied Sciences
Transonic buffet flow is a classical complex and unstable flow that has a negative effect on aircraft fly safety. Therefore, it is crucial to study the unsteady characteristics of buffet flow. The numerical analysis method is very useful in achieving the
Xueyuan Nie, Guannan Zheng, Lianyi Wei, Chengde Huang, Guowei Yang, Zhanling Ji   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Data-Driven Adaptive Control of Transonic Buffet via Localized Morphing Skin

Aerospace
Transonic shock buffet, characterized by large-amplitude self-sustained shock oscillations arising from shock wave/boundary layer interactions, poses significant challenges to aircraft handling quality and structural integrity.
Yuchen Zhang, Lianyi Wei, Yiqiu Jin, Han Tang, Guannan Zheng, Guowei Yang   +5 more
doaj   +1 more source

Research on aerodynamic optimization of high-speed train’s slipstream

Engineering Applications of Computational Fluid Mechanics, 2020
Slipstream severely affects the safety of trackside workers and equipment. With use of profile superimposition method and vehicle modeling method, parametrization of the whole train is carried out. Then, a slipstream optimization study has been performed,
Zhenxu Sun, Shuanbao Yao, Guowei Yang
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Multiscale simulation of heat transfer in a rarefied gas [PDF]

, 2014
We present a new hybrid method for dilute gas flows that couples a continuum- fluid description to the direct simulation Monte Carlo (DSMC) technique.
Borg, Matthew Karl, Lockerby, Duncan A., Docherty, Stephanie, Reese, Jason   +3 more
core   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Numerical visualization of drop and opening process for parachute-payload system adopting fluid–solid coupling simulation

Journal of Vision, 2021
In order to study the fluid–solid coupling dynamic characteristics of parachute-payload system during drop process and analyze the unsteady aerodynamic characteristics under finite mass opening conditions, an adaptive moving fluid mesh method is ...
Bin-Qi Chen, Yiding Wang, Chen-Di Zhao, Yi Sun, Lei-Ming Ning   +4 more
semanticscholar   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source