Results 31 to 40 of about 6,039,684 (252)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

ON INTERACTION BETWEEN FALLING BODIES AND THE SURROUNDING FLUID [PDF]

, 2010
Interactions between a finite number of bodies and the surrounding fluid, in a channel for instance, are investigated theoretically. In the planar model here the bodies or modelled grains are thin solid bodies free to move in a nearly parallel formation ...
Ellis, AS, Smith, FT
core  

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Numerical study of a Flexible Sail Plan submitted to pitching : Hysteresis phenomenon and effect of rig Adjustments [PDF]

, 2014
Yacht sails dynamic fluid structure interaction is simulated in harmonic pitching Aerodynamic forces show hysteresis associated to energy dissipation Dissipated energy increases with pitching frequency and amplitude Hysteresis is cancelled and forces ...
AUGIER, Benoit, BOT, Patrick, DURAND, Mathieu, AUBIN, Nicolas, HAUVILLE, Frederic   +4 more
core   +1 more source

Distributed Computational Method for Coupled Fluid Structure Thermal Interaction Applications

Journal of Algorithms & Computational Technology, 2010
The problem of effcient modeling and computation of the nonlinear interaction of fluid with a solid undergoing nonlinear deformation has remained a challenging problem in computational science and engineering.
E. Aulisa, S. Manservisi, P. Seshaiyer, A. Idesman   +3 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Nonlinear seepage mechanical model and bifurcation analysis for fluid-solid coupling in fractured rock mass

Scientific Reports
With the development of underground engineering and oil and gas exploitation, the problem of fluid-solid interaction in fractured rock mass has become increasingly prominent, and its complex coupling mechanism has a profound impact on the stability and ...
Cao Zhengzheng, Xie Mengqi, Rong Tao, Du Feng, Li Zhenhua, Wang Wenqiang   +5 more
doaj   +1 more source

Dynamic Analysis of Shear Flows over a Porous Medium in a Cylindrical Tube

Advances in Mechanical Engineering, 2013
Dynamic responses of a viscous fluid flow introduced under a time dependent pressure gradient in a rigid cylindrical tube subject to deformable porous surface layer have been investigated.
J. P. Dwivedi, V. P. Singh, Radha Krishna Lal   +2 more
doaj   +1 more source

Improving SPH Fluid Simulation Using Position Based Dynamics

IEEE Access, 2017
Physical-based simulation technique has been widely used in creating astounding fluid appearances for film industries and computer games. However, stable and realistic fluid simulation based on Smoothed Particle Hydrodynamics (SPH) method is still ...
Xuqiang Shao, Erchong Liao, Fengquan Zhang   +2 more
doaj   +1 more source