Results 41 to 50 of about 6,039,684 (252)

A Dynamic Fluid-solid Interaction Model for Virtual Implantation of Coronary Stents

open access: yesJournal of Harbin University of Science and Technology, 2021
A sequential fluid-solid interaction model of expanded coronary-shear thinning blood is developed accounting for effect of both stent and vessel deformation on haemodynamics.
JIANG XU-dong, XU Xin-bo, TENG Xiao-yan
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

An immersed transitional interface finite element method for fluid interacting with rigid/deformable solid

open access: yesEngineering Applications of Computational Fluid Mechanics, 2019
An immersed transitional interface finite element method (ITI-FEM) is proposed to simulate fluid-structure interaction (FSI). In the framework of finite element method (FEM), the Navier-Stokes equations and the dynamic equation for solid are integrated ...
Xiang Liu, Lisheng Liu
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Research on the Vibration Characteristics for Membrane Structures Considering Fluid–Solid Interaction

open access: yesAdvances in Civil Engineering
Flexible roofing systems, including membrane structures, exhibit high sensitivity to wind loads due to their lightweight and flexible design. The impact of fluid–solid interaction on the vibrational behavior of membrane structures needs to be considered ...
Qingqing Yan, Yiding Zhao, Wei Kong
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Finite element method to fluid-solid interaction problems with unbounded periodic interfaces [PDF]

open access: yes, 2014
Consider a time-harmonic acoustic plane wave incident onto a doubly periodic (biperiodic) surface from above. The medium above the surface is supposed to be filled with a homogeneous compressible inviscid fluid of constant mass density, whereas the ...
Andreas Rathsfeld   +5 more
core   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Numerical Simulation of Two-Phase Flow and Analysis of Fluid-Structure Interaction of Fracturing Fluid in High Pressure Elbow

open access: yesShiyou jixie, 2020
It is of great significance to analyze the fracturing fluid solid-liquid two-phase flow and the stress and vibration of high-pressure elbow caused by the fluid-structure interaction effects.
Yang Siqi, Fan Jianchun, Zhang Laibin
doaj  

Iteratively Coupled Flow and Geomechanics in Fractured Poroelastic Reservoirs: A Phase Field Fracture Model

open access: yesGeofluids, 2021
Fluid-solid coupling in fractured reservoirs plays a critical role for optimizing and managing in energy and geophysical engineering. Computational difficulties associated with sharp fracture models motivate phase field fracture modeling.
Jinzhou Zhao   +8 more
doaj   +1 more source

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