Results 71 to 80 of about 71,922 (264)
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Shock and Vibration, 2019 A 1.5 MW horizontal-axis wind turbine blade and fluid field model are established to study the difference in the unsteady flow field and structural vibration of the wind turbine blade under one- and two-way fluid-structure interactions.
Rui Zhu, Da-duo Chen, Shi-wei Wu
doaj +1 more source
Impact Response of the Tail Beam Jack Based on Bidirectional Fluid-Structure Coupling Simulation. [PDF]
ACS Omega, 2023 Zhu Y, Zeng Q, Wan L, Li Z, Ma D.
europepmc +1 more source
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Fluid-Structure Coupling Effects in a Dual U-Tube Coriolis Mass Flow Meter. [PDF]
Sensors (Basel), 2021 Hu YC, Chen ZY, Chang PZ.
europepmc +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Strong coupling for fluid structure interaction problems
European Journal of Computational Mechanics, 2007 The computation of fluid forces acting on a rigid or deformable structure constitutes a major problem in fluid structure interaction. However, the majority of numerical tests consists in using two different codes to separately solve pressure of the fluid and structural displacements.
Naji, H. +2 more
openaire +4 more sources
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Jixie qiangdu, 2023 Wind turbine blade pitch fault is easy to cause unstable ultra-high load, which can lead to structural failure and damage. Firstly, the aerodynamic characteristics of NREL 5 MW wind turbine blades with pitch fault/success were analyzed based on the ...
GAO Wei +4 more
doaj