Results 51 to 60 of about 71,922 (264)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Fluid Structure Interaction Using Modal Superposition and Lagrangian CFD

Journal of Marine Science and Engineering
This study investigates the impact of fluid loads on the elastic deformation and dynamic response of linear structures. A weakly coupled modal solver is presented, which involves the solution of a dynamic equation of motion with external loads.
Manigandan Paneer, Josip Bašić, Damir Sedlar, Željan Lozina, Nastia Degiuli, Chong Peng   +5 more
doaj   +1 more source

Coupling analysis of contra-rotating fan interstage pressure pulsation and blade vibration based on wavelet reconstruction.

PLoS ONE, 2021
In recent years, the flow characteristics research of the interstage region in counter-rotating axial fans in terms of fluid dynamics has attracted much attention.
Xinzhe Zhang, Chen Dai, Zunlong Jin, Sławomir Dykas, Guojie Zhang   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Stability Analysis of a Partitioned Fluid–Structure Thermal Coupling Algorithm

Journal of Thermophysics and Heat Transfer, 2012
Numerical multiphysics coupling is gaining more and more importance in engineering. Partitioned algorithms are among the most efficient methods to solve the coupled problem. However, they present some drawbacks, with the stability of the algorithm itself being the crucial one.
Joshi Ojas, Leyland Pénélope
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Fluid-structure Coupling Simulation Analysis of Angular Contact Ball Bearing

Jixie chuandong, 2021
The lubrication condition of angular contact ball bearings in operation is crucial，and the lubricant directly affects the contact state of rolling bearings. In order to analyze the lubrication condition of angular contact ball bearings and the mechanical
Lanwen Wang, Xuanyu Sheng, Jianbin Luo
doaj  

Performance Optimization of Interacting Sails Through Fluid Structure Coupling

Innovation in High Performance Sailing Yachts 2010, 2010
In this paper, the problem of sailing yacht rig design has been addressed through the development of a computational framework based on viscous Computational Fluid Dynamic (CFD) modelling for the aerodynamic part and on a non linear structural modelling for the structure part. The Fluid Structure Interaction (FSI) coupling used is a loose coupling. The
Chapin, Vincent, Carlan, Nolwenn de, Heppel, Peter   +2 more
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Numeric Analysis Method of Fluid-Solid Coupling Vibration in Train Passing by Each Other at High Speed

机车电传动, 2013
In order to study safety of train passing by each other with consideration of fluid-solid coupling friendship and avoid the large damage to structure and running safety from the interaction of train and air, a new numerical analysis method of fluid-solid
CUI Tao, ZHANG Wei-hua, WANG Yan
doaj